Optimizing the quantity/quality trade-off in connectome inference

DOI10.1080/03610926.2011.630768zbMATH Open1466.62416arXiv1108.6271OpenAlexW2964344400MaRDI QIDQ2864656FDOQ2864656

Carey E. Priebe, Joshua T. Vogelstein, Davi Bock

Publication date: 26 November 2013

Published in: Communications in Statistics. Theory and Methods (Search for Journal in Brave)

Abstract: We demonstrate a meaningful prospective power analysis for an (admittedly idealized) illustrative connectome inference task. Modeling neurons as vertices and synapses as edges in a simple random graph model, we optimize the trade-off between the number of (putative) edges identified and the accuracy of the edge identification procedure. We conclude that explicit analysis of the quantity/quality trade-off is imperative for optimal neuroscientific experimental design. In particular, more though more errorful edge identification can yield superior inferential performance.

Full work available at URL: https://arxiv.org/abs/1108.6271

Recommendations

• A Bayesian compressed-sensing approach for reconstructing neural connectivity from subsampled anatomical data
• Fast state-space methods for inferring dendritic synaptic connectivity
• Sequential Optimal Design of Neurophysiology Experiments
• Optimal wiring in the cortex and neuronal degree of separation
• Consistent estimation of complete neuronal connectivity in large neuronal populations using sparse ``shotgun neuronal activity sampling

zbMATH Keywords

experimental designgraph theoryneuroscience

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

This page was built for publication: Optimizing the quantity/quality trade-off in connectome inference

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2864656)