Optimizing the quantity/quality trade-off in connectome inference

DOI10.1080/03610926.2011.630768MaRDI QIDQ2864656zbMATH OpenOpenAlexFDO

Authors Davi Bock, Carey E. Priebe, Joshua T. Vogelstein

Publication date 26 November 2013

Published in Communications in Statistics. Theory and Methods (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1108.6271

zbMATH Keywords

experimental designgraph theoryneuroscience

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: We demonstrate a meaningful prospective power analysis for an (admittedly idealized) illustrative connectome inference task. Modeling neurons as vertices and synapses as edges in a simple random graph model, we optimize the trade-off between the number of (putative) edges identified and the accuracy of the edge identification procedure. We conclude that explicit analysis of the quantity/quality trade-off is imperative for optimal neuroscientific experimental design. In particular, more though more errorful edge identification can yield superior inferential performance.

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