Analysis of a nonlocal model for spontaneous cell polarization

DOI10.1137/11083486XMaRDI QIDQ2903533zbMATH OpenOpenAlexWikidataFDO

Authors Vincent Calvez, Rhoda J. Hawkins, Nicolas Meunier, Raphael Voituriez

Publication date 10 August 2012

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1105.4429

zbMATH Keywords

Keller-Segel systemdrift-diffusion equation

Mathematics Subject Classification ID

Blow-up in context of PDEs (35B44) Continuation and prolongation of solutions to PDEs (35B60) PDEs in connection with biology, chemistry and other natural sciences (35Q92) General biology and biomathematics (92B05) Cell movement (chemotaxis, etc.) (92C17)

Abstract: In this work, we investigate the dynamics of a non-local model describing spontaneous cell polarisation. It consists in a drift-diffusion equation set in the half-space, with the coupling involving the trace value on the boundary. We characterize the following behaviours in the one-dimensional case: solutions are global if the mass is below the critical mass and they blow-up in finite time above the critical mass. The higher-dimensional case is also discussed. The results are reminiscent of the classical Keller-Segel system in double the dimension. In addition, in the one-dimensional case we prove quantitative convergence results using relative entropy techniques. This work is complemented with a more realistic model that takes into account dynamical exchange of molecular content at the boundary. In the one-dimensional case we prove that blow-up is prevented. Furthermore, density converges towards a non trivial stationary configuration.

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• Global existence for a bulk/surface model for active-transport-induced polarisation in biological cells
• Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways
• Stability of a non-local kinetic model for cell migration with density-dependent speed
• A stochastic model for protrusion activity
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• A PDE-DDE model for cell polarization in fission yeast

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