A stochastic model for protrusion activity

DOI10.1051/PROC/201862056MaRDI QIDQ4615453zbMATH OpenOpenAlexWikidataFDO

Authors Christèle Etchegaray, Nicolas Meunier

Publication date 28 January 2019

Published in ESAIM: Proceedings and Surveys (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1808.00217

zbMATH Keywords

Markov processcell migrationcell polarisationcell velocityprotrusive forces

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Cell movement (chemotaxis, etc.) (92C17)

Abstract: In this work we approach cell migration under a large-scale assumption, so that the system reduces to a particle in motion. Unlike classical particle models, the cell displacement results from its internal activity: the cell velocity is a function of the (discrete) protrusive forces exerted by filopodia on the substrate. Cell polarisation ability is modeled in the feedback that the cell motion exerts on the protrusion rates: faster cells form preferentially protrusions in the direction of motion. By using the mathematical framework of structured population processes previously developed to study population dynamics [Fournier and M{'e}l{'e}ard, 2004], we introduce rigorously the mathematical model and we derive some of its fundamental properties. We perform numerical simulations on this model showing that different types of trajectories may be obtained: Brownian-like, persistent, or intermittent when the cell switches between both previous regimes. We find back the trajectories usually described in the literature for cell migration.

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Cites work

• A microscopic probabilistic description of a locally regulated population and macroscopic approximations
• Analysis of a nonlocal model for spontaneous cell polarization

Cited in

(3)

• A stimulating mechanism in an active system: General model
• Persistent random motion: uncovering cell migration dynamics
• Crawling migration under chemical signalling: a stochastic model

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