Trade-offs in delayed information transmission in biochemical networks

DOI10.1007/S10955-015-1332-8MaRDI QIDQ290459zbMATH OpenOpenAlexFDO

Authors F. Mancini, M. Marsili, A. M. Walczak

Publication date 1 June 2016

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1504.03637

zbMATH Keywords

optimizationenergy dissipationbiochemical regulatory networksinformation transmissionstochastic circuits

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Feedback control (93B52)

Abstract: In order to transmit biochemical signals, biological regulatory systems dissipate energy with concomitant entropy production. Additionally, signaling often takes place in challenging environmental conditions. In a simple model regulatory circuit given by an input and a delayed output, we explore the trade-offs between information transmission and the system's energetic efficiency. We determine the maximally informative network, given a fixed amount of entropy production and delayed response, exploring both the case with and without feedback. We find that feedback allows the circuit to overcome energy constraints and transmit close to the maximum available information even in the dissipationless limit. Negative feedback loops, characteristic of shock responses, are optimal at high dissipation. Close to equilibrium positive feedback loops, known for their stability, become more informative. Asking how the signaling network should be constructed to best function in the worst possible environment, rather than an optimally tuned one or in steady state, we discover that at large dissipation the same universal motif is optimal in all of these conditions.

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Cites work

• scientific article; zbMATH DE number 3106184 (Why is no real title available?)
• An introduction to systems biology. Design principles of biological circuits.
• Decisions on the fly in cellular sensory systems
• Efficiency of cellular information processing
• Nonequilibrium measurements of free energy differences for microscopically reversible Markovian systems
• Positional information, in bits
• Robust model matching control of immune systems under environmental disturbances: dynamic game approach
• Stochastic thermodynamics of bipartite systems: transfer entropy inequalities and a Maxwell’s demon interpretation
• Thermodynamic limits to information harvesting by sensory systems

Cited in

(9)

• Performance limits and trade-offs in entropy-driven biochemical computers
• Binding of transcription factors adapts to resolve information-energy tradeoff
• Detecting concentration changes with cooperative receptors
• On signalling and estimation limits for molecular birth-processes
• Prediction and dissipation in nonequilibrium molecular sensors: conditionally Markovian channels driven by memoryful environments
• Cascade of transitions in molecular information theory
• Tradeoffs in simple biomolecular signaling systems
• What we learn from the learning rate
• Tradeoffs in adapting biological systems

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