Detecting concentration changes with cooperative receptors

DOI10.1007/S10955-015-1354-2MaRDI QIDQ290495zbMATHOpenAlexFDO

Authors Stefano Bo, A. Celani

Publication date 1 June 2016

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1507.07386

zbMATH Keywords

hypothesis testingstochastic processescooperativitysensing

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Biochemistry, molecular biology (92C40) Cell biology (92C37)

Abstract: Cells constantly need to monitor the state of the environment to detect changes and timely respond. The detection of concentration changes of a ligand by a set of receptors can be cast as a problem of hypothesis testing, and the cell viewed as a Neyman-Pearson detector. Within this framework, we investigate the role of receptor cooperativity in improving the cell's ability to detect changes. We find that cooperativity decreases the probability of missing an occurred change. This becomes especially beneficial when difficult detections have to be made. Concerning the influence of cooperativity on how fast a desired detection power is achieved, we find in general that there is an optimal value at finite levels of cooperation, even though easy discrimination tasks can be performed more rapidly by noncooperative receptors.

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Cites work

• scientific article; zbMATH DE number 107482 (Why is no real title available?)
• Decisions on the fly in cellular sensory systems
• Efficiency of cellular information processing
• Mutual entropy production in bipartite systems
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Cited in

(2)

• Know the single-receptor sensing limit? Think again
• Chemoreception by a cell with age-dependent receptor binding sites

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