Detecting concentration changes with cooperative receptors

DOI10.1007/S10955-015-1354-2zbMATH Open1337.92043arXiv1507.07386OpenAlexW1631124002MaRDI QIDQ290495FDOQ290495

A. Celani, Stefano Bo

Publication date: 1 June 2016

Published in: Journal of Statistical Physics (Search for Journal in Brave)

Abstract: Cells constantly need to monitor the state of the environment to detect changes and timely respond. The detection of concentration changes of a ligand by a set of receptors can be cast as a problem of hypothesis testing, and the cell viewed as a Neyman-Pearson detector. Within this framework, we investigate the role of receptor cooperativity in improving the cell's ability to detect changes. We find that cooperativity decreases the probability of missing an occurred change. This becomes especially beneficial when difficult detections have to be made. Concerning the influence of cooperativity on how fast a desired detection power is achieved, we find in general that there is an optimal value at finite levels of cooperation, even though easy discrimination tasks can be performed more rapidly by noncooperative receptors.

Full work available at URL: https://arxiv.org/abs/1507.07386

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zbMATH Keywords

hypothesis testingstochastic processescooperativitysensing

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Biochemistry, molecular biology (92C40) Cell biology (92C37)

Cites Work

• Title not available (Why is that?)
• Trade-offs in delayed information transmission in biochemical networks
• Mutual entropy production in bipartite systems
• Efficiency of cellular information processing
• Nonequilibrium sensing and its analogy to kinetic proofreading
• Decisions on the fly in cellular sensory systems
• Positional information, in bits

Cited In (1)

• Chemoreception by a cell with age-dependent receptor binding sites

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