Biological implications of dynamical phases in non-equilibrium networks

DOI10.1007/S10955-015-1445-0MaRDI QIDQ290472zbMATH OpenOpenAlexFDO

Authors Arvind Murugan, Suriyanarayanan Vaikuntanathan

Publication date 1 June 2016

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1506.02323

zbMATH Keywords

biological networksdynamical phase transitionsinformation processing

Mathematics Subject Classification ID

Large deviations (60F10) Systems biology, networks (92C42)

Abstract: Biology achieves novel functions like error correction, ultra-sensitivity and accurate concentration measurement at the expense of free energy through Maxwell Demon-like mechanisms. The design principles and free energy trade-offs have been studied for a variety of such mechanisms. In this review, we emphasize a perspective based on dynamical phases that can explain commonalities shared by these mechanisms. Dynamical phases are defined by typical trajectories executed by non-equilibrium systems in the space of internal states. We find that coexistence of dynamical phases can have dramatic consequences for function vs free energy cost trade-offs. Dynamical phases can also provide an intuitive picture of the design principles behind such biological Maxwell Demons.

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Cited in

(2)

• Network thermodynamics of biological systems: a bond graph approach
• Processive and distributive non-equilibrium networks discriminate in alternate limits

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