Geometric path integrals. A language for multiscale biology and systems robustness

DOI10.1007/978-88-470-1947-8_16MaRDI QIDQ2905009zbMATH OpenOpenAlexFDO

Authors Emanuel Petricoin, D. C. Struppa, Domenico Napoletani

Publication date 24 August 2012

Published in The Mathematical Legacy of Leon Ehrenpreis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1108.5399

Mathematics Subject Classification ID

Systems biology, networks (92C42) Path integrals in quantum mechanics (81S40)

Abstract: In this paper we suggest that, under suitable conditions, supervised learning can provide the basis to formulate at the microscopic level quantitative questions on the phenotype structure of multicellular organisms. The problem of explaining the robustness of the phenotype structure is rephrased as a real geometrical problem on a fixed domain. We further suggest a generalization of path integrals that reduces the problem of deciding whether a given molecular network can generate specific phenotypes to a numerical property of a robustness function with complex output, for which we give heuristic justification. Finally, we use our formalism to interpret a pointedly quantitative developmental biology problem on the allowed number of pairs of legs in centipedes.

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Cited in

(1)

• Path integral formulation and Feynman rules for phylogenetic branching models

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