Optimal design for population PK/PD models

DOI10.2478/V10127-012-0012-1MaRDI QIDQ2913241zbMATH OpenOpenAlexFDO

Authors Alexander Aliev, Sergei Leonov

Publication date 26 September 2012

Published in Tatra Mountains Mathematical Publications (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.2478/v10127-012-0012-1

zbMATH Keywords

\(D\)-optimalityFisher information matrixcompartmental modelsoptimal model-based designPK/PD models

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05)

Recommendations

• Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics
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Cites work

• scientific article; zbMATH DE number 438984 (Why is no real title available?)
• scientific article; zbMATH DE number 3913478 (Why is no real title available?)
• scientific article; zbMATH DE number 192992 (Why is no real title available?)
• scientific article; zbMATH DE number 194144 (Why is no real title available?)
• scientific article; zbMATH DE number 5196540 (Why is no real title available?)
• Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics
• Model-oriented design of experiments
• PkStaMp library for constructing optimal population designs for PK/PD studies
• Sequences converging to D-optimal designs of experiments
• The Sequential Generation of $D$-Optimum Experimental Designs

Cited in

(7)

• Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics
• Optimal Sampling Times in Population Pharmacokinetic Studies
• Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics
• Evaluation of the Fisher information matrix in nonlinear mixed effect models using adaptive Gaussian quadrature
• PkStaMp library for constructing optimal population designs for PK/PD studies
• Mathematics of pharmacokinetics and pharmacodynamics: diversity of topics, models and methods
• Optimal parametric design with applications to pharmacokinetic and pharmacodynamic trials

Describes a project that uses

Uses Software

• PkStaMp
• Monolix

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