Optimal design for population PK/PD models

DOI10.2478/V10127-012-0012-1zbMATH Open1313.62114OpenAlexW2076724474MaRDI QIDQ2913241FDOQ2913241

Authors: Alexander Aliev, Sergei Leonov 

Publication date: 26 September 2012

Published in: Tatra Mountains Mathematical Publications (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.2478/v10127-012-0012-1

Recommendations

• Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics
• Optimal parametric design with applications to pharmacokinetic and pharmacodynamic trials
• Optimal design in random-effects regression models
• Optimal Sampling Times in Population Pharmacokinetic Studies
• PkStaMp library for constructing optimal population designs for PK/PD studies

zbMATH Keywords

\(D\)-optimalityFisher information matrixcompartmental modelsoptimal model-based designPK/PD models

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05)

Cites Work

• PkStaMp library for constructing optimal population designs for PK/PD studies
• Title not available (Why is that?)
• The Sequential Generation of $D$-Optimum Experimental Designs
• Title not available (Why is that?)
• Title not available (Why is that?)
• Model-oriented design of experiments
• Title not available (Why is that?)
• Title not available (Why is that?)
• Sequences converging to D-optimal designs of experiments
• Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics

Cited In (7)

• Optimal parametric design with applications to pharmacokinetic and pharmacodynamic trials
• Evaluation of the Fisher information matrix in nonlinear mixed effect models using adaptive Gaussian quadrature
• Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics
• Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics
• Mathematics of pharmacokinetics and pharmacodynamics: diversity of topics, models and methods
• Optimal Sampling Times in Population Pharmacokinetic Studies
• PkStaMp library for constructing optimal population designs for PK/PD studies

Uses Software

• PkStaMp
• Monolix

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