The authors discuss the relation between different definitions of cooperative binding and present some examples to show differences between the concepts of cooperativity. It is shown that among the considered definitions there are not two which fully coincide. To see the relation between the definitions of cooperativity on the micro- and macrostates, the authors give examples showing that negative cooperativity on the microscopic level can produce phenomena which are assigned to positive cooperative ligand binding.
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Cites work
- A derivation of the grand canonical partition function for systems with a finite number of binding sites using a Markov chain model for the dynamics of single molecules
- A mathematical view on the decoupled sites representation
- Asymptotics of quantum relative entropy from a representation theoretical viewpoint.
- scientific article; zbMATH DE number 1246635 (Why is no real title available?)
- scientific article; zbMATH DE number 6282188 (Why is no real title available?)
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(10)- A model for cooperative ligand binding at complementary sites of DNA
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- A measure to quantify the degree of cooperativity in overall titration curves
- Minimal models of multi-site ligand-binding kinetics
- Cooperativity, absolute interaction, and algebraic optimization
- A model for carrier-mediated biological signal transduction based on equilibrium ligand binding theory
- On Hill coefficients and subunit interaction energies
- On the relation of different definitions of cooperative binding for systems with two binding sites
- The significance of noise in the evolution of negative and positive cooperativity in protein complexes
- Sigmoidicity in allosteric models
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