Evolution of viral life-cycle in response to cytotoxic T lymphocyte-mediated immunity

DOI10.1016/J.JTBI.2012.06.020MaRDI QIDQ292732zbMATH OpenOpenAlexWikidataFDO

Authors Yoram Louzoun, Vitaly V. Ganusov

Publication date 9 June 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2012.06.020

zbMATH Keywords

dynamicsepitopesevolutionimmunologyODE

Mathematics Subject Classification ID

Medical epidemiology (92C60) Epidemiology (92D30)

Recommendations

• Optimal viral immune surveillance evasion strategies
• Evolutionary principles in viral epitopes
• Optimizing within-host viral fitness: infected cell lifespan and virion production rate
• Immune Responses against Conserved and Variable Viral Epitopes
• Some basic properties of immune selection

Cites work

• Evaluating the importance of within- and between-host selection pressures on the evolution of chronic pathogens
• Evolution of virulence: interdependence, constraints, and selection using nested models
• HIV time hierarchy: winning the war while, loosing all the battles
• Optimal viral immune surveillance evasion strategies
• Optimal viral production
• Optimizing within-host viral fitness: infected cell lifespan and virion production rate
• Trade-offs and the evolution of virulence of microparasites: do details matter?

Cited in

(5)

• The function of temporally ordered viral gene expression in the intracellular replication of herpes simplex virus type 1 (HSV-1)
• Viral reproductive strategies: how can lytic viruses be evolutionarily competitive?
• Evolutionary principles in viral epitopes
• The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)
• On the relative fitness of early and late stage Simian immunodeficiency virus isolates

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Uses Software

• DEDiscover

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