Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited

DOI10.1016/J.JTBI.2012.07.012MaRDI QIDQ293763zbMATHOpenAlexWikidataFDO

Authors Yangqing Xu, Jeremy Gunawardena

Publication date 9 June 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc3432734

zbMATH Keywords

robustnessinvariantGoldbeter-Koshland looplinear frameworkzero-order ultrasensitivity

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

• Operating regimes of covalent modification cycles at high enzyme concentrations
• The dynamics of zeroth-order ultrasensitivity: a critical phenomenon in cell biology
• Zero-order ultrasensitivity: a study of criticality and fluctuations under the total quasi-steady state approximation in the linear noise regime
• Ultrasensitivity in independent multisite systems
• Ultrasensitivity and sharp threshold theorems for multisite systems

Cites work

• scientific article; zbMATH DE number 3047763 (Why is no real title available?)
• An algebraic approach to signaling cascades with \(n\) layers
• Complex-linear invariants of biochemical networks
• Non-stationary vibration of multilayer plates of a non-canonical form. The elastic immersion method
• The rational parameterisation theorem for multisite post-translational modification systems

Cited in

(14)

• Ultrasensitivity in independent multisite systems
• Monostationarity and multistationarity in tree networks of Goldbeter-Koshland loops
• The dynamics of zeroth-order ultrasensitivity: a critical phenomenon in cell biology
• Analysis of substrate competition in regulatory network motifs: stimulus-response curves, thresholds and ultrasensitivity
• Superiority of single covalent modification in specificity: from deterministic to stochastic viewpoint
• Zero-order ultrasensitivity: a study of criticality and fluctuations under the total quasi-steady state approximation in the linear noise regime
• Operating regimes of covalent modification cycles at high enzyme concentrations
• Laplacian dynamics on general graphs
• Ultrasensitivity and sharp threshold theorems for multisite systems
• Kinetic behavior of the general modifier mechanism of Botts and Morales with non-equilibrium binding
• The effect of site-to-site variability in ultrasensitive dose responses
• Analysis of the fractional modification of the monocyclic enzyme cascades, defined in an alternative way involving the two forms of the modified protein
• Complex-linear invariants of biochemical networks
• Laplacian dynamics with synthesis and degradation

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