The dynamics of zeroth-order ultrasensitivity: a critical phenomenon in cell biology

DOI10.3934/DCDSS.2011.4.1457MaRDI QIDQ542541zbMATH OpenOpenAlexFDO

Authors Qingdao Huang, Hong Qian

Publication date 10 June 2011

Published in Discrete and Continuous Dynamical Systems. Series S (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1205.6219

zbMATH Keywords

cooperative processesPdPC

Mathematics Subject Classification ID

Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: It is well known since the pioneering work of Goldbeter and Koshland [Proc. Natl. Acad. Sci. USA, vol. 78, pp. 6840-6844 (1981)] that cellular phosphorylation- dephosphorylation cycle (PdPC), catalyzed by kinase and phosphatase under saturated condition with zeroth order enzyme kinetics, exhibits ultrasensitivity, sharp transition. We analyse the dynamics aspects of the zeroth order PdPC kinetics and show a critical slowdown akin to the phase transition in condensed matter physics. We demonstrate that an extremely simple, though somewhat mathematically "singular" model is a faithful representation of the ultrasentivity phenomenon. The simplified mathematical model will be valuable, as a component, in developing complex cellular signaling network theory as well as having a pedagogic value.

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(5)

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• Zero-order ultrasensitivity: a study of criticality and fluctuations under the total quasi-steady state approximation in the linear noise regime
• Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited
• Ultrasensitive dual phosphorylation dephosphorylation cycle kinetics exhibits canonical competition behavior
• Multisite Mechanisms for Ultrasensitivity in Signal Transduction

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