Mathematical modeling of drug resistance due to KRAS mutation in colorectal cancer

DOI10.1016/J.JTBI.2015.10.019MaRDI QIDQ304779zbMATH OpenOpenAlexWikidataFDO

Authors Sheema Sameen, Roberto Barbuti, Paolo Milazzo, Antonio Cerone, Marzia Del Re, Romano Danesi

Publication date 26 August 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2015.10.019

zbMATH Keywords

colorectal cancermathematical modelKRAS mutationmonoclonal antibody resistance

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell biology (92C37)

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Cites work

• Mathematical modeling of monoclonal conversion in the colonic crypt
• Modelling chemotherapy resistance in palliation and failed cure
• The influence of toxicity constraints in models of chemotherapeutic protocol escalation

Cited in

(5)

• Mathematical modeling and analysis of ErbB3 and EGFR dimerization process for the gefitinib resistance
• Overcoming drug resistance to BRAF inhibitor
• A mathematical model for progression and heterogeneity in colorectal cancer dynamics
• Phase-specific cancer-immune model considering acquired resistance to therapeutic agents
• Mathematical modeling of the dimerization of EGFR and ErbB3 in lung adenocarcinoma

Describes a project that uses

Uses Software

• Octave

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