Mixed-mode oscillations in a three time-scale system of ODEs motivated by a neuronal model
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Publication:3069837
DOI10.1080/14689360903535760zbMATH Open1204.37085arXiv0804.0829OpenAlexW2002280945MaRDI QIDQ3069837FDOQ3069837
Authors: Jozsi Jalics, M. Krupa, Horacio G. Rotstein 
Publication date: 20 January 2011
Published in: Dynamical Systems (Search for Journal in Brave)
Abstract: We analyze a biophysical model of a neuron from the entorhinal cortex that includes persistent sodium and slow potassium as non-standard currents using reduction of dimension and dynamical systems techniques to determine the mechanisms for the generation of mixed-mode oscillations. We have found that the standard spiking currents (sodium and potassium) play a critical role in the analysis of the interspike interval. To study the mixed-mode oscillations, the six dimensional model has been reduced to a three dimensional model for the subthreshold regime. Additional transformations and a truncation have led to a simplified model system with three timescales that retains many properties of the original equations, and we employ this system to elucidate the underlying structure and explain a novel mechanism for the generation of mixed-mode oscillations based on the canard phenomenon. In particular, we prove the existence of a special solution, a singular primary canard, that serves as a transition between mixed-mode oscillations and spiking in the singular limit by employing appropriate rescalings, center manifold reductions, and energy arguments. Additionally, we conjecture that the singular canard solution is the limit of a family of canards and provide numerical evidence for the conjecture.
Full work available at URL: https://arxiv.org/abs/0804.0829
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Dynamical systems in biology (37N25) Neural biology (92C20) Relaxation oscillations for ordinary differential equations (34C26)
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Cited In (21)
- Mixed-mode oscillations in a three-timescale coupled Morris-Lecar system
- Complex oscillatory motion of multiple spikes in a three-component Schnakenberg system
- Mixed-mode oscillations in a three time-scale model for the dopaminergic neuron
- The selection of mixed-mode oscillations in a Hodgkin-Huxley model with multiple timescales
- Mixed mode oscillations and synchronous activity in noise induced modified Morris-Lecar neural system
- The shaping of intrinsic membrane potential oscillations: positive/negative feedback, ionic resonance/amplification, nonlinearities and time scales
- Subthreshold amplitude and phase resonance in models of quadratic type: nonlinear effects generated by the interplay of resonant and amplifying currents
- Timescales and mechanisms of sigh-like bursting and spiking in models of rhythmic respiratory neurons
- Multi-timescale systems and fast-slow analysis
- Interaction of canard and singular Hopf mechanisms in a neural model
- Low-dimensional models of single neurons: a review
- Complex oscillatory dynamics in a three-timescale El Niño southern oscillation model
- Geometric blow-up for folded limit cycle manifolds in three time-scale systems
- Understanding and distinguishing three-time-scale oscillations: case study in a coupled Morris-Lecar system
- Analysis of interacting local oscillation mechanisms in three-timescale systems
- Canards, Clusters, and Synchronization in a Weakly Coupled Interneuron Model
- Wild oscillations in a nonlinear neuron model with resets. II: Mixed-mode oscillations
- Mixed-mode bursting oscillations: dynamics created by a slow passage through spike-adding canard explosion in a square-wave burster
- Canard Induced Mixed-Mode Oscillations in a Medial Entorhinal Cortex Layer II Stellate Cell Model
- Bifurcations of mixed-mode oscillations in three-timescale systems: an extended prototypical example
- Canard-induced complex oscillations in an excitatory network
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