Estimation and Inference for a Spline-Enhanced Population Pharmacokinetic Model

DOI10.1111/j.0006-341X.2002.00601.xzbMath1210.62179OpenAlexW1980416356WikidataQ48621737 ScholiaQ48621737MaRDI QIDQ3078995

Kyunghoon Lee, Morton B. Brown, Suneel Gupta, Lang Li

Publication date: 1 March 2011

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.0006-341x.2002.00601.x

zbMATH Keywords

Runge-Kutta methodmulticompartment modelsnatural cubic splinedouble penalized log-likelihood function

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Multistep, Runge-Kutta and extrapolation methods for ordinary differential equations (65L06) Estimation in survival analysis and censored data (62N02)

Related Items (11)

A Population Pharmacokinetic Model with Time-Dependent Covariates Measured with Errors ⋮ Parameter estimation for semiparametric ordinary differential equation models ⋮ Bayesian inference of mixed-effects ordinary differential equations models using heavy-tailed distributions ⋮ Manifold-constrained Gaussian process inference for time-varying parameters in dynamic systems ⋮ Semiparametric modeling of autonomous nonlinear dynamical systems with application to plant growth ⋮ Sieve estimation of constant and time-varying coefficients in nonlinear ordinary differential equation models by considering both numerical error and measurement error ⋮ Selection Strategy for Covariance Structure of Random Effects in Linear Mixed-effects Models ⋮ Comments on: Dynamic relations for sparsely sampled Gaussian processes ⋮ Smooth functional tempering for nonlinear differential equation models ⋮ Generalized Ordinary Differential Equation Models ⋮ Parameter Estimation of Partial Differential Equation Models

Cites Work

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• A comparison of GCV and GML for choosing the smoothing parameter in the generalized spline smoothing problem
• Variance Function Estimation
• Semiparametric Stochastic Mixed Models for Longitudinal Data
• Inference in Generalized Additive Mixed Models by Using Smoothing Splines
• Laplace's approximation for nonlinear mixed models
• Bayesian inference for variance components using only error contrasts

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