Optimal estimation for the functional Cox model

DOI10.1214/16-AOS1441zbMATH Open1345.62028arXiv1601.07496MaRDI QIDQ309740FDOQ309740

Jane-Ling Wang, Simeng Qu, Xiao Wang

Publication date: 7 September 2016

Published in: The Annals of Statistics (Search for Journal in Brave)

Abstract: Functional covariates are common in many medical, biodemographic, and neuroimaging studies. The aim of this paper is to study functional Cox models with right-censored data in the presence of both functional and scalar covariates. We study the asymptotic properties of the maximum partial likelihood estimator and establish the asymptotic normality and efficiency of the estimator of the finite-dimensional estimator. Under the framework of reproducing kernel Hilbert space, the estimator of the coefficient function for a functional covariate achieves the minimax optimal rate of convergence under a weighted $L_2$-risk. This optimal rate is determined jointly by the censoring scheme, the reproducing kernel and the covariance kernel of the functional covariates. Implementation of the estimation approach and the selection of the smoothing parameter are discussed in detail. The finite sample performance is illustrated by simulated examples and a real application.

Full work available at URL: https://arxiv.org/abs/1601.07496

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zbMATH Keywords

asymptotic normalityfunctional dataCox modelefficiencypartial likelihoodright-censored dataminimax rate of convergence

Mathematics Subject Classification ID

Nonparametric estimation (62G05) Censored data models (62N01) Estimation in survival analysis and censored data (62N02) Minimax procedures in statistical decision theory (62C20)

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Cited In (11)

• LCox: a tool for selecting genes related to survival outcomes using longitudinal gene expression data
• Modelling time-varying covariates effect on survival via functional data analysis: application to the MRC BO06 trial in osteosarcoma
• Semiparametric Inference for the Functional Cox Model
• Optimal estimation for the functional Cox model
• Using persistent homology topological features to characterize medical images: case studies on lung and brain cancers
• Semiparametric estimation for the functional additive hazards model
• FLCRM: Functional linear cox regression model
• Cox regression models with functional covariates for survival data
• Additive Functional Cox Model
• Functional Censored Quantile Regression
• Subgroup analysis in the heterogeneous Cox model

Uses Software

• fda (R)
• gss

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