Study Duration for Clinical Trials with Survival Response and Early Stopping Rule

DOI10.2307/2531632zbMATH Open0715.62247OpenAlexW2317811229WikidataQ68809187 ScholiaQ68809187MaRDI QIDQ3201550FDOQ3201550

KyungMann Kim, Anastasios A. Tsiatis

Publication date: 1990

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.2307/2531632

Recommendations

• Planning the duration of a survival group sequential trial with a fixed follow-up time for all subjects
• Duration of accrual and follow-up for two-stage clinical trials
• A two-sample parametric group sequential procedure for monitoring clinical trials
• Stopping rules for long-term clinical trials based on two consecutive rejections of the null hypothesis
• scientific article; zbMATH DE number 1157175

zbMATH Keywords

log-rank testsurvival analysisproportional hazards modelinformation timecomparative clinical trialgroup sequential design and analysisuse function

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Cited In (3)

• Monitoring phase II comparative clinical trials with two endpoints and penalty for adverse events
• Duration of accrual and follow-up for two-stage clinical trials
• Survival Analysis with Time-Varying Regression Effects Using a Tree-Based Approach

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