Phase-field model of cell motility: traveling waves and sharp interface limit
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Publication:321489
DOI10.1016/J.CRMA.2016.09.001zbMATH Open1349.92036arXiv1604.02749OpenAlexW2963374575MaRDI QIDQ321489FDOQ321489
Authors: Leonid Berlyand, Mykhailo Potomkin, V. Rybalko 
Publication date: 13 October 2016
Published in: Comptes Rendus. Mathématique. Académie des Sciences, Paris (Search for Journal in Brave)
Abstract: This letter is concerned with asymptotic analysis of a PDE model for motility of a eukaryotic cell on a substrate. This model was introduced in [1], where it was shown numerically that it successfully reproduces experimentally observed phenomena of cell-motility such as a discontinuous onset of motion and shape oscillations. The model consists of a parabolic PDE for a scalar phase-field function coupled with a vectorial parabolic PDE for the actin filament network (cytoskeleton). We formally derive the sharp interface limit (SIL), which describes the motion of the cell membrane and show that it is a volume preserving curvature driven motion with an additional nonlinear term due to adhesion to the substrate and protrusion by the cytoskeleton. In a 1D model problem we rigorously justify the SIL, and, using numerical simulations, observe some surprising features such as discontinuity of interface velocities and hysteresis. We show that nontrivial traveling wave solutions appear when the key physical parameter exceeds a certain critical value and the potential in the equation for phase field function possesses certain asymmetry.
Full work available at URL: https://arxiv.org/abs/1604.02749
Recommendations
Traveling wave solutions (35C07) Reaction-diffusion equations (35K57) Cell movement (chemotaxis, etc.) (92C17)
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Cited In (15)
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- Sharp interface analysis of a diffuse interface model for cell blebbing with linker dynamics
- Bifurcation of traveling waves in a Keller-Segel type free boundary model of cell motility
- Moving boundary problem for a one-dimensional crawling nematode sperm cell model
- Self polarization and traveling wave in a model for cell crawling migration
- A Cahn-Hilliard model for cell motility
- Cell polarity and movement with reaction-diffusion and moving boundary: rigorous model analysis and robust simulations
- Uniqueness and traveling waves in a cell motility model
- Travelling-wave behaviour in a multiphase model of a population of cells in an artificial scaffold
- Phase field model for cell spreading dynamics
- Excitable dynamics in a molecularly-explicit model of cell motility: mixed-mode oscillations and beyond
- Sharp interface limit in a phase field model of cell motility
- On an evolution equation in a cell motility model
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