Sharp interface analysis of a diffuse interface model for cell blebbing with linker dynamics

DOI10.1002/ZAMM.202300101arXiv2302.04612MaRDI QIDQ6148902FDOQ6148902

Harald Garcke, Martin Burger, Author name not available (Why is that?)

Publication date: 8 February 2024

Published in: ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik (Search for Journal in Brave)

Abstract: We investigate the convergence of solutions of a recently proposed diffuse interface/phase field model for cell blebbing by means of matched asymptotic expansions. It is a biological phenomenon that increasingly attracts attention by both experimental and theoretical communities. Key to understanding the process of cell blebbing mechanically are proteins that link the cell cortex and the cell membrane. Another important model component is the bending energy of the cell membrane and cell cortex which accounts for differential equations up to sixth order. Both aspects pose interesting mathematical challenges that will be addressed in this work like showing non-singularity formation for the pressure at boundary layers, deriving equations for asymptotic series coefficients of uncommonly high order, and dealing with a highly coupled system of equations.

Full work available at URL: https://arxiv.org/abs/2302.04612

zbMATH Keywords

boundary layerscell blebbinginterface/phase field model

Mathematics Subject Classification ID

Singular perturbations in context of PDEs (35B25) Asymptotic expansions of solutions to PDEs (35C20) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biomechanics (92C10)

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