Sharp interface analysis of a diffuse interface model for cell blebbing with linker dynamics

DOI10.1002/ZAMM.202300101MaRDI QIDQ6148902FDO

Authors Martin Burger, Harald Garcke

Publication date 8 February 2024

Published in ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2302.04612

zbMATH Keywords

boundary layerscell blebbinginterface/phase field model

Mathematics Subject Classification ID

Singular perturbations in context of PDEs (35B25) Asymptotic expansions of solutions to PDEs (35C20) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biomechanics (92C10)

Abstract: We investigate the convergence of solutions of a recently proposed diffuse interface/phase field model for cell blebbing by means of matched asymptotic expansions. It is a biological phenomenon that increasingly attracts attention by both experimental and theoretical communities. Key to understanding the process of cell blebbing mechanically are proteins that link the cell cortex and the cell membrane. Another important model component is the bending energy of the cell membrane and cell cortex which accounts for differential equations up to sixth order. Both aspects pose interesting mathematical challenges that will be addressed in this work like showing non-singularity formation for the pressure at boundary layers, deriving equations for asymptotic series coefficients of uncommonly high order, and dealing with a highly coupled system of equations.

Recommendations

• A PDE model for bleb formation and interaction with linker proteins
• A diffuse interface model for cell blebbing including membrane-cortex coupling with linker dynamics
• A Cahn-Hilliard model for cell motility
• Phase-field model of cell motility: traveling waves and sharp interface limit
• Three mechanical models for blebbing and multi-blebbing

Cites work

• scientific article; zbMATH DE number 3654574 (Why is no real title available?)
• scientific article; zbMATH DE number 193842 (Why is no real title available?)
• scientific article; zbMATH DE number 798177 (Why is no real title available?)
• A PDE model for bleb formation and interaction with linker proteins
• A computational model of bleb formation
• A diffuse interface model for cell blebbing including membrane-cortex coupling with linker dynamics
• A poroelastic immersed boundary method with applications to cell biology
• A variational approach to moving contact line hydrodynamics
• Asymptotic Analysis of Phase Field Formulations of Bending Elasticity Models
• Energetic variational approaches in modeling vesicle and fluid interactions
• Phase-field approximation of the Willmore flow
• Sharp interface limit for a Stokes/Allen-Cahn system

This page was built for publication: Sharp interface analysis of a diffuse interface model for cell blebbing with linker dynamics

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6148902)