Adjusting Simon'S optimal two-stage design for heterogeneous populations based on stratification or using historical controls

DOI10.1002/BIMJ.201800390MaRDI QIDQ3299096zbMATH OpenOpenAlexWikidataFDO

Authors Dominic Edelmann, Christina Habermehl, Richard F. Schlenk, Axel Benner

Publication date 17 July 2020

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201800390

zbMATH Keywords

clinical trialheterogeneous populationadaptive designstratified designhistorical control

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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• Sample size estimation for cancer randomized trials in the presence of heterogeneous populations

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