Adjusting Simon'S optimal two-stage design for heterogeneous populations based on stratification or using historical controls

DOI10.1002/BIMJ.201800390zbMATH Open1436.62545OpenAlexW2976710596WikidataQ90274114 ScholiaQ90274114MaRDI QIDQ3299096FDOQ3299096

Authors: Dominic Edelmann, Christina Habermehl, Richard F. Schlenk, Axel Benner 

Publication date: 17 July 2020

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.201800390

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zbMATH Keywords

clinical trialheterogeneous populationadaptive designstratified designhistorical control

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cited In (3)

• Using real-world data to predict health outcomes -- the prediction design: application and sample size planning
• A batch‐effect adjusted Simon's two‐stage design for cancer vaccine clinical studies
• Sample size estimation for cancer randomized trials in the presence of heterogeneous populations

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