Optimal adaptive two-stage designs for phase II cancer clinical trials

DOI10.1002/BIMJ.201200220MaRDI QIDQ2858002zbMATH OpenOpenAlexWikidataFDO

Authors Stefan Englert, Meinhard Kieser

Publication date 19 November 2013

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201200220

zbMATH Keywords

branch-and-bound algorithmsample sizetwo-stage designadaptive designphase II clinical trial

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping
• Adaptive Two-Stage Designs for Single-Arm Phase IIA Cancer Clinical Trials
• Improving the flexibility and efficiency of phase II designs for oncology trials
• Designs for Group Sequential Phase II Clinical Trials
• Adaptive clinical trial designs for phase I cancer studies

Cites work

• Adaptive Two-Stage Designs for Single-Arm Phase IIA Cancer Clinical Trials
• Designed Extension of Studies Based on Conditional Power
• Improving the flexibility and efficiency of phase II designs for oncology trials

Cited in

(17)

• Optimal exact design of double acceptance sampling plans by attributes
• Two-stage design for phase II oncology trials with relaxed futility stopping
• MULTINOMIAL PHASE II CANCER TRIALS INCORPORATING RESPONSE AND EARLY PROGRESSION
• Improving the flexibility and efficiency of phase II designs for oncology trials
• On optimal subset designs for phase II clinical trials with both total response and disease control
• Exact confidence limits after a group sequential single arm binary trial
• Random norming AIDS analysis of non-linear regression models with sequential informative dose selection
• Adaptive Two-Stage Designs for Single-Arm Phase IIA Cancer Clinical Trials
• Bayesian enhancement two-stage design with error control for phase II clinical trials
• Optimal planning of adaptive two-stage designs
• A batch‐effect adjusted Simon's two‐stage design for cancer vaccine clinical studies
• Bayesian adaptive two-stage design for determining person-time in phase II clinical trials with Poisson data
• Randomized phase II cancer clinical trials
• New results on optimal conditional error functions for adaptive two-stage designs
• Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping
• Adjusting Simon'S optimal two-stage design for heterogeneous populations based on stratification or using historical controls
• An optimal design in a two-stage ethical allocation based on U-statistics

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