Random norming AIDS analysis of non-linear regression models with sequential informative dose selection
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Publication:2301071
Abstract: A two-stage adaptive optimal design is an attractive option for increasing the efficiency of clinical trials. In these designs, based on interim data, the locally optimal dose is chosen for further exploration, which induces dependencies between data from the two stages. When the maximum likelihood estimator (MLE) is used under nonlinear regression models with independent normal errors in a pilot study where the first stage sample size is fixed, and the second stage sample size is large, the Fisher information fails to normalize the estimator adequately asymptotically, because of dependencies. In this situation, we present three alternative random information measures and show that they provide better normalization of the MLE asymptotically. The performance of random information measures is investigated in simulation studies, and the results suggest that the observed information performs best when the sample size is small.
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Cites work
- A birth and death urn for randomized clinical trials: asymptotic methods
- A Review of Some Aspects of Asymptotic Likelihood Theory for Stochastic Processes
- A Two-Sample Test for a Linear Hypothesis Whose Power is Independent of the Variance
- Adaptive designs for dose-finding based on efficacy-toxicity response
- Adaptive designs for selecting drug combinations based on efficacy-toxicity response
- Assessing the accuracy of the maximum likelihood estimator: Observed versus expected Fisher information
- Asymptotic properties of maximum likelihood estimators with sample size recalculation
- Asymptotics in response-adaptive designs generated by a two-color, randomly reinforced urn
- Bayesian enrichment strategies for randomized discontinuation trials
- Bayesian optimal designs for phase I clinical trials
- Bias reduction of maximum likelihood estimates
- Conditional Estimation in Two-Stage Adaptive Designs
- scientific article; zbMATH DE number 3723610 (Why is no real title available?)
- scientific article; zbMATH DE number 3227597 (Why is no real title available?)
- scientific article; zbMATH DE number 3090541 (Why is no real title available?)
- Information in a two-stage adaptive optimal design
- On mixing and stability of limit theorems
- Optimal adaptive two-stage designs for phase II cancer clinical trials
- Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment
- Stable convergence and stable limit theorems
- Two-stage adaptive optimal design with fixed first-stage sample size
Cited in
(5)- On the efficiency of nonparametric variance estimation in sequential dose-finding
- Inference for a two-stage enrichment design
- Efficiency of observed information adaptive designs in linear models
- Optimal relevant subset designs in nonlinear models
- The effects of adaptation on maximum likelihood inference for nonlinear models with normal errors
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