Asymptotics in response-adaptive designs generated by a two-color, randomly reinforced urn

DOI10.1214/08-AOS596zbMath1162.62076arXiv0904.0350MaRDI QIDQ1020992

Caterina May, Nancy Flournoy

Publication date: 4 June 2009

Published in: The Annals of Statistics (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/0904.0350

zbMATH Keywords

rate of convergenceasymptotic normalityadaptive designsclinical trialsoptimal allocationtreatment allocationmixing convergenceethical allocationestimation and inferencegeneralized Pólya urntesting mean differencestwo-sample t-test

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Central limit and other weak theorems (60F05) Strong limit theorems (60F15) Sequential statistical design (62L05) Asymptotic properties of parametric tests (62F05)

Related Items (23)

An urn model with random multiple drawing and random addition ⋮ A simple solution to the inadequacy of asymptotic likelihood-based inference for response-adaptive clinical trials: likelihood-based inference for RAR trials ⋮ Randomly Reinforced Urn Designs with Prespecified Allocations ⋮ Distribution theory following blinded and unblinded sample size re-estimation under parametric models ⋮ Information in a two-stage adaptive optimal design ⋮ A functional equation whose unknown is \(\mathcal{P}([0,1)\) valued] ⋮ Asymptotic properties of maximum likelihood estimators with sample size recalculation ⋮ Statistical test for an urn model with random multidrawing and random addition ⋮ Statistical properties of two-color randomly reinforced urn design targeting fixed allocations ⋮ A Central Limit Theorem and its Applications to Multicolor Randomly Reinforced Urns ⋮ On a notion of partially conditionally identically distributed sequences ⋮ Nonparametric covariate-adjusted response-adaptive design based on a functional urn model ⋮ Asymptotic Properties of Multicolor Randomly Reinforced Pólya Urns ⋮ Conditionally identically distributed species sampling sequences ⋮ An urn model to construct an efficient test procedure for response adaptive designs ⋮ Central limit theorems for multicolor urns with dominated colors ⋮ Fluctuation theorems for synchronization of interacting Pólya's urns ⋮ Random norming AIDS analysis of non-linear regression models with sequential informative dose selection ⋮ A central limit theorem, and related results, for a two-color randomly reinforced urn ⋮ Efficiency of observed information adaptive designs in linear models ⋮ Central limit theorems for an Indian buffet model with random weights ⋮ Infinite-color randomly reinforced urns with dominant colors ⋮ A conversation with Nancy Flournoy

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