Asymptotics in response-adaptive designs generated by a two-color, randomly reinforced urn
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asymptotic normalityclinical trialsrate of convergenceadaptive designsoptimal allocationtreatment allocationmixing convergenceethical allocationestimation and inferencetesting mean differencestwo-sample t-testgeneralized Pólya urn
Asymptotic properties of parametric estimators (62F12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Asymptotic properties of parametric tests (62F05) Sequential statistical design (62L05) Central limit and other weak theorems (60F05) Strong limit theorems (60F15)
Abstract: This paper illustrates asymptotic properties for a response-adaptive design generated by a two-color, randomly reinforced urn model. The design considered is optimal in the sense that it assigns patients to the best treatment, with probability converging to one. An approach to show the joint asymptotic normality of the estimators of the mean responses to the treatments is provided in spite of the fact that allocation proportions converge to zero and one. Results on the rate of convergence of the number of patients assigned to each treatment are also obtained. Finally, we study the asymptotic behavior of a suitable test statistic.
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Cited in
(29)- Randomly Reinforced Urn Designs with Prespecified Allocations
- A conversation with Nancy Flournoy
- On a notion of partially conditionally identically distributed sequences
- Information in a two-stage adaptive optimal design
- Stochastic recursive techniques in response-adaptive designs
- Asymptotic properties of multicolor randomly reinforced Pólya urns
- Statistical properties of two-color randomly reinforced urn design targeting fixed allocations
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- A functional equation whose unknown is \(\mathcal{P}([0,1])\) valued
- Efficiency of observed information adaptive designs in linear models
- Asymptotically optimal response-adaptive designs for allocating the best treatment: an overview
- Asymptotic normality of urn models for clinical trials with delayed response
- Random norming AIDS analysis of non-linear regression models with sequential informative dose selection
- Central limit theorems for an Indian buffet model with random weights
- Conditional information and inference in response-adaptive allocation designs
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- A central limit theorem, and related results, for a two-color randomly reinforced urn
- Conditionally identically distributed species sampling sequences
- Statistical test for an urn model with random multidrawing and random addition
- An urn model with random multiple drawing and random addition
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