The Theory of Response‐Adaptive Randomization in Clinical Trials

DOI10.1002/047005588XzbMATH Open1111.62107MaRDI QIDQ5490901FDOQ5490901

Authors William F. Rosenberger, Feifang Hu 

Publication date 4 October 2006

Published in Wiley Series in Probability and Statistics (Search for Journal in Brave)

zbMATH Keywords

Sample size determinationML estimatorsUrn modelsSequential estimationClinical trials

Mathematics Subject Classification ID

Point estimation (62F10) Nonparametric estimation (62G05) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential estimation (62L12) Research exposition (monographs, survey articles) pertaining to statistics (62-02)

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Cited in

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• Response-adaptive treatment allocation for non-inferiority trials with heterogeneous variances
• Response-Adaptive Randomization for Survival Trials: The Parametric Approach
• Response-adaptive randomization for multi-arm clinical trials using the forward looking Gittins index rule
• Adaptive Designs to Maximize Power in Clinical Trials with Multiple Treatments
• Statistical properties of two-color randomly reinforced urn design targeting fixed allocations
• scientific article; zbMATH DE number 1817583 (Why is no real title available?)
• On recent advances in optimal allocation designs in clinical trials
• A new design strategy for hypothesis testing under response adaptive randomization
• Longitudinal covariate-adjusted response-adaptive randomized designs
• Web-based statistical tools for the analysis and design of clinical trials that incorporate historical controls
• Randomised response-adaptive designs in clinical trials
• Randomization in clinical trials. Theory and practice
• Response adaptive designs for phase II trials with binary endpoint based on context-dependent information measures
• An optimal response-adaptive design with dual constraints
• Efficient randomized-adaptive designs
• Asymptotically best response-adaptive randomization procedures
• A randomized two stage allocation for continuous response clinical trials
• Optimal response-adaptive allocation designs in phase III clinical trials: incorporating ethics in optimality
• Adaptive crossover design for normal responses
• A semiparametric sequential algorithm for estimation of dose-response curve
• Implementing optimal allocation for sequential continuous responses with multiple treatments
• Adaptative Designs for Multi-Arm Clinical Trials: The Play-the-Winner Rule Revisited
• Asymptotically efficient estimation in response adaptive trials
• Doubly adaptive biased coin designs with heterogeneous responses
• Sequential Monitoring of Conditional Randomization Tests: Generalized Biased Coin Designs
• Covariate-adaptive designs with missing covariates in clinical trials
• Handling covariates in the design of clinical trials
• Statistical analysis of non-inferiority via non-zero risk difference in stratified matched-pair studies
• Sequential methods in multi-arm clinical trials
• Bayesian phase II adaptive randomization by jointly modeling time-to-event efficacy and binary toxicity
• Bayesian doubly adaptive randomization in clinical trials
• Some recent developments in the design of adaptive clinical trials
• Drop-the-loser design in the presence of covariates
• Multiple-objective response-adaptive repeated measurement designs for clinical trials
• Response adaptive designs with misclassified responses
• Sequential and two-stage fixed-width confidence interval estimation in response-adaptive designs
• One-armed bandit process with a covariate
• On a notion of partially conditionally identically distributed sequences
• Doubly adaptive biased coin designs with delayed responses
• Selecting a biased-coin design
• Implementing optimal allocation in clinical trials with multiple endpoints
• A Bayesian adaptive design for clinical trials in rare diseases
• Sequential monitoring of response-adaptive randomized clinical trials
• Optimality, Variability, Power
• A comparison of allocation strategies for optimising clinical trial designs under variance heterogeneity
• Inference after covariate-adaptive randomisation: aspects of methodology and theory
• Combination of Levene-type tests and a finite-intersection method for testing equality of variances against ordered alternatives
• On the almost sure convergence of adaptive allocation procedures
• Multi-objective optimal designs in comparative clinical trials with covariates: the reinforced doubly adaptive biased coin design
• Asymptotic properties of covariate-adaptive randomization
• Novel Bayesian Adaptive Designs and Their Applications in Cancer Clinical Trials
• Variance-penalized response-adaptive randomization with mismeasurement
• Covariate-adjusted response-adaptive designs for generalized linear models
• A new family of covariate-adjusted response adaptive designs and their properties
• An optimal allocation for response-adaptive designs
• Asymptotics in response-adaptive designs generated by a two-color, randomly reinforced urn
• Response‐Adaptive Randomization for Clinical Trials with Continuous Outcomes
• Interval estimation for response adaptive clinical trials
• An optimal response adaptive biased coin design with \(k\) heteroscedastic treatments
• Immigrated urn models-theoretical properties and applications
• Mean and variance of balanced Pólya urns
• Compound adaptive GPU design for clinical trials
• Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule
• A response-driven adaptive design based on the Klein urn
• The Gaussian approximation for multi-color generalized Friedman's urn model
• Covariate-adjusted response-adaptive designs based on semiparametric approaches
• Response-adaptive treatment allocation for clinical studies with recurrent event and terminal event data
• A simple solution to the inadequacy of asymptotic likelihood-based inference for response-adaptive clinical trials: likelihood-based inference for RAR trials
• Implementation of adaptive randomizations for clinical trials
• Allocation in platform trials to maintain comparability across time and eligibility
• Matching on-the-fly: sequential allocation with higher power and efficiency
• A new inferential approach for response-adaptive clinical trials: the variance-stabilized bootstrap
• Response adaptive intervention allocation in stepped-wedge cluster randomized trials
• A Bayesian-bandit adaptive design for \(N\)-of-1 clinical trials
• Optimal designs for testing the efficacy of heterogeneous experimental groups
• Simulation of clinical trials: a review with emphasis on the design issues
• An optimal sequential design in ethical allocation with an adaptive interim analysis
• Stopping Rules in Balanced Allocation Problems: Exact and Asymptotic Distributions
• Bayesian adaptive randomization with compound utility functions
• Nonparametric covariate-adjusted response-adaptive design based on a functional urn model
• Asymptotic properties of multicolor randomly reinforced Pólya urns
• Implementing unequal randomization in clinical trials with heterogeneous treatment costs
• Response-adaptive randomization in clinical trials: from myths to practical considerations
• Subgroup analysis and adaptive experiments crave for debiasing
• A covariate-adjusted response-adaptive allocation for a general class of continuous responses
• Power efficiency of Efron's biased coin design
• A more credible approach to parallel trends
• A welfare analysis of occupational licensing in U.S. states
• Hazed and confused: the effect of air pollution on dementia
• IQ, expectations, and choice
• Optimal feedback in contests
• Save, spend, or give? A model of housing, family insurance, and savings in old age
• Stratification trees for adaptive randomisation in randomised controlled trials
• Testing the production approach to markup estimation
• Unemployment insurance in macroeconomic stabilization
• Doubly adaptive biased coin design to improve Bayesian clinical trials with time-to-event endpoints
• An urn model to construct an efficient test procedure for response adaptive designs
• A two armed optimal response adaptive randomization for ordinal categorical responses with possible misclassification
• Statistical test for an urn model with random multidrawing and random addition
• On the performance of the Neyman Allocation with small pilots

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