Response-adaptive randomization for multi-arm clinical trials using the forward looking Gittins index rule

DOI10.1111/BIOM.12337zbMATH Open1419.62465OpenAlexW1537383030WikidataQ36868286 ScholiaQ36868286MaRDI QIDQ2809522FDOQ2809522

Authors: Sofía S. Villar, Jack Bowden, James Wason 

Publication date: 30 May 2016

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/biom.12337

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zbMATH Keywords

clinical trialsGittins indexmulti-armed banditsequential allocationBayesian adaptive designs

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Cites Work

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• Optimal adaptive designs for binary response trials
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• The Theory of Response‐Adaptive Randomization in Clinical Trials
• Optimal adaptive randomized designs for clinical trials
• Randomized allocation with nonparametric estimation for a multi-armed bandit problem with covariates
• Optimality, Variability, Power
• Implementing Optimal Allocation in Sequential Binary Response Experiments
• On the Gittins index in the M/G/1 queue

Cited In (18)

• A response-adaptive randomization procedure for multi-armed clinical trials with normally distributed outcomes
• A Markov decision process for response-adaptive randomization in clinical trials
• Response adaptive designs for phase II trials with binary endpoint based on context-dependent information measures
• Bayesian adaptive bandit-based designs using the Gittins index for multi-armed trials with normally distributed endpoints
• A Bayesian adaptive design for clinical trials in rare diseases
• A simple solution to the inadequacy of asymptotic likelihood-based inference for response-adaptive clinical trials: likelihood-based inference for RAR trials
• Implementing unequal randomization in clinical trials with heterogeneous treatment costs
• Response-adaptive randomization for multiarm clinical trials using context-dependent information measures
• Doubly adaptive biased coin design to improve Bayesian clinical trials with time-to-event endpoints
• Bandit strategies evaluated in the context of clinical trials in rare life-threatening diseases
• Generalisations of a Bayesian decision-theoretic randomisation procedure and the impact of delayed responses
• A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule
• Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule
• Using biomarkers to allocate patients in a response-adaptive clinical trial
• The performance of fixed-horizon, look-ahead procedures compared to backward induction in Bayesian adaptive-randomization decision-theoretic clinical trial design
• Response-adaptive randomization in clinical trials: from myths to practical considerations
• Rejoinder: response-adaptive randomization in clinical trials
• Gittins indices and constrained allocation in clinical trials

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