A new family of covariate-adjusted response adaptive designs and their properties

DOI10.1007/S11766-009-0001-6zbMATH Open1198.62167arXiv0812.3691OpenAlexW3101896592MaRDI QIDQ846774FDOQ846774

Authors: Lixin Zhang, Feifang Hu 

Publication date: 12 February 2010

Published in: Applied Mathematics. Series B (English Edition) (Search for Journal in Brave)

Abstract: It is often important to incorporating covariate information in the design of clinical trials. In literature, there are many designs of using stratification and covariate-adaptive randomization to balance on certain known covariate. Recently Zhang, Hu, Cheung and Chan (2007) have proposed a family of covariate-adjusted response-adaptive (CARA) designs and studied their asymptotic properties. However, these CARA designs often have high variabilities. In this paper, we propose a new family of covariate-adjusted response-adaptive (CARA) designs. We show that the new designs have smaller variabilities and therefore more efficient.

Full work available at URL: https://arxiv.org/abs/0812.3691

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zbMATH Keywords

covariatesefficiencyasymptotic variability

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

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Cited In (15)

• A covariate-adjusted response-adaptive allocation for a general class of continuous responses
• A general characterization of optimal tie-breaker designs
• Nonparametric covariate-adjusted response-adaptive design based on a functional urn model
• Multi-objective optimal designs in comparative clinical trials with covariates: the reinforced doubly adaptive biased coin design
• Covariate-adjusted response-adaptive designs for censored survival responses
• Handling covariates in the design of clinical trials
• Sequential estimation for covariate-adjusted response-adaptive designs
• Covariate-adjusted response-adaptive designs for generalized linear models
• Asymptotic properties of covariate-adjusted response-adaptive designs
• Covariate‐adjusted response adaptive designs incorporating covariates with and without treatment interactions
• Inference in targeted group-sequential covariate-adjusted randomized clinical trials
• A unified family of covariate-adjusted response-adaptive designs based on efficiency and ethics
• On the almost sure convergence of adaptive allocation procedures
• Title not available (Why is that?)
• Adaptive crossover design for normal responses

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