A new family of covariate-adjusted response adaptive designs and their properties
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Abstract: It is often important to incorporating covariate information in the design of clinical trials. In literature, there are many designs of using stratification and covariate-adaptive randomization to balance on certain known covariate. Recently Zhang, Hu, Cheung and Chan (2007) have proposed a family of covariate-adjusted response-adaptive (CARA) designs and studied their asymptotic properties. However, these CARA designs often have high variabilities. In this paper, we propose a new family of covariate-adjusted response-adaptive (CARA) designs. We show that the new designs have smaller variabilities and therefore more efficient.
Recommendations
- A unified family of covariate-adjusted response-adaptive designs based on efficiency and ethics
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- Handling covariates in the design of clinical trials
- Sequential estimation for covariate-adjusted response-adaptive designs
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Cited in
(15)- Sequential estimation for covariate-adjusted response-adaptive designs
- Adaptive crossover design for normal responses
- Nonparametric covariate-adjusted response-adaptive design based on a functional urn model
- Handling covariates in the design of clinical trials
- A covariate-adjusted response-adaptive allocation for a general class of continuous responses
- scientific article; zbMATH DE number 5005886 (Why is no real title available?)
- Asymptotic properties of covariate-adjusted response-adaptive designs
- A unified family of covariate-adjusted response-adaptive designs based on efficiency and ethics
- Covariate‐adjusted response adaptive designs incorporating covariates with and without treatment interactions
- A general characterization of optimal tie-breaker designs
- On the almost sure convergence of adaptive allocation procedures
- Multi-objective optimal designs in comparative clinical trials with covariates: the reinforced doubly adaptive biased coin design
- Covariate-adjusted response-adaptive designs for generalized linear models
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- Inference in targeted group-sequential covariate-adjusted randomized clinical trials
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