A unified family of covariate-adjusted response-adaptive designs based on efficiency and ethics

DOI10.1080/01621459.2014.903846MaRDI QIDQ5367369zbMATHOpenAlexWikidataFDO

Authors Jianhua Hu, Hongjian Zhu, Feifang Hu

Publication date 13 October 2017

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc4478080

zbMATH Keywords

asymptotic propertiespowerrandomizationgeneralized linear modelsclinical trialpersonalized medicinecovariate-adjusted response-adaptive (CARA) designs

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Generalized linear models (logistic models) (62J12) Applications of statistics to social sciences (62P25) Response surface designs (62K20)

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Cited in

(15)

• Covariate-adjusted response-adaptive designs based on semiparametric approaches
• Response-adaptive treatment allocation for clinical studies with recurrent event and terminal event data
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• Nonparametric covariate-adjusted response-adaptive design based on a functional urn model
• Covariate-adaptive designs with missing covariates in clinical trials
• Handling covariates in the design of clinical trials
• Response-adaptive randomization in clinical trials: from myths to practical considerations
• Subgroup analysis and adaptive experiments crave for debiasing
• Doubly adaptive biased coin design to improve Bayesian clinical trials with time-to-event endpoints
• A general characterization of optimal tie-breaker designs
• Generalized Efron's biased coin design and its theoretical properties
• A new family of covariate-adjusted response adaptive designs and their properties
• A practical response adaptive block randomization (RABR) design with analytic type I error protection
• Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule
• Dynamic Causal Effects Evaluation in A/B Testing with a Reinforcement Learning Framework

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