Asymptotic properties of covariate-adjusted response-adaptive designs

DOI10.1214/009053606000001424MaRDI QIDQ2642745zbMATH OpenOpenAlexFDO

Authors Siu Hung Cheung, Lixin Zhang, Feifang Hu, Wai Sum Chan

Publication date 4 September 2007

Published in The Annals of Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0610518

zbMATH Keywords

adaptive designsasymptotic normalityclinical trialcovariate informationlogistic regression

Mathematics Subject Classification ID

Central limit and other weak theorems (60F05) Strong limit theorems (60F15) Asymptotic properties of nonparametric inference (62G20) Generalized linear models (logistic models) (62J12) Sequential statistical design (62L05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: Response-adaptive designs have been extensively studied and used in clinical trials. However, there is a lack of a comprehensive study of response-adaptive designs that include covariates, despite their importance in clinical experiments. Because the allocation scheme and the estimation of parameters are affected by both the responses and the covariates, covariate-adjusted response-adaptive (CARA) designs are very complex to formulate. In this paper, we overcome the technical hurdles and lay out a framework for general CARA designs for the allocation of subjects to $K(geq2)$ treatments. The asymptotic properties are studied under certain widely satisfied conditions. The proposed CARA designs can be applied to generalized linear models. Two important special cases, the linear model and the logistic regression model, are considered in detail.

Recommendations

• Covariate‐adjusted response adaptive designs incorporating covariates with and without treatment interactions
• A new family of covariate-adjusted response adaptive designs and their properties
• Covariate-adjusted response-adaptive designs for generalized linear models
• Sequential estimation for covariate-adjusted response-adaptive designs
• A covariate-adjusted response-adaptive allocation for a general class of continuous responses

Cites work

• Adaptive designs for normal responses with prognostic factors
• Allocation by randomized play-the-winner rule in the presence of prognostic factors
• An Application of an Urn Model to the Design of Sequential Controlled Clinical Trials
• Asymptotic normality of maximum likelihood estimators from multiparameter response-driven designs
• Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials.
• Bayesian Adaptive Biased‐Coin Designs for Clinical Trials with Normal Responses
• Central limit theorems for doubly adaptive biased coin designs
• Forcing a sequential experiment to be balanced
• scientific article; zbMATH DE number 3945130 (Why is no real title available?)
• scientific article; zbMATH DE number 3723610 (Why is no real title available?)
• scientific article; zbMATH DE number 1348603 (Why is no real title available?)
• scientific article; zbMATH DE number 2102890 (Why is no real title available?)
• On the Large Sample Optimality of Sequential Designs for Comparing Two or More Treatments
• On the use of generalized linear models following a sequential design
• Optimality, Variability, Power
• Optimum biased coin designs for sequential clinical trials with prognostic factors
• Some aspects of the sequential design of experiments
• The Comparison of Designs for Sequential Clinical Trials with Covariate Information

Cited in

(57)

• Optimal response and covariate-adaptive biased-coin designs for clinical trials with continuous multivariate or longitudinal responses
• Response-adaptive treatment allocation for non-inferiority trials with heterogeneous variances
• Fixed-width confidence interval for covariate-adjusted response-adaptive designs
• Nonparametric covariate-adjusted response-adaptive design based on a functional urn model
• On the asymptotic inference for response-adaptive experiments
• On recent advances in optimal allocation designs in clinical trials
• A covariate-adjusted response-adaptive allocation for a general class of continuous responses
• On the almost sure convergence of adaptive allocation procedures
• Covariate-adjusted response-adaptive designs for generalized linear models
• Two-treatment covariate-dependent response adaptive allocation design for dichotomous response
• Sequential estimation for covariate-adjusted response-adaptive designs
• Selecting a biased-coin design
• Multi-arm covariate-adaptive randomization
• Adaptive clinical trial designs to detect interaction between treatment and a dichotomous biomarker
• Multi-treatment covariate-adjusted adaptive design under informative censoring
• On Multi-Treatment Adaptive Allocation Design for Dichotomous Response
• Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule
• Generalized Efron's biased coin design and its theoretical properties
• Covariate‐adjusted response adaptive designs incorporating covariates with and without treatment interactions
• Longitudinal covariate-adjusted response-adaptive randomized designs
• Response adaptive designs with asymptotic optimality
• Adaptive crossover design for normal responses
• A unified family of covariate-adjusted response-adaptive designs based on efficiency and ethics
• Inference in targeted group-sequential covariate-adjusted randomized clinical trials
• scientific article; zbMATH DE number 5041089 (Why is no real title available?)
• Inference after covariate-adaptive randomisation: aspects of methodology and theory
• Balancing Unobserved Covariates With Covariate-Adaptive Randomized Experiments
• An optimal multiarmed response adaptive design for survival outcome with independent censoring
• Dynamic Causal Effects Evaluation in A/B Testing with a Reinforcement Learning Framework
• Covariate-adjusted response-adaptive designs for censored survival responses
• A general characterization of optimal tie-breaker designs
• Comment: a quarter century of methodological research in response-adaptive randomization
• Anytime-Valid Tests of Conditional Independence Under Model-X
• Covariate-adjusted response-adaptive designs based on semiparametric approaches
• Subgroup analysis and adaptive experiments crave for debiasing
• Adaptive randomization for balancing over covariates
• Response-adaptive treatment allocation for clinical studies with recurrent event and terminal event data
• Comparison of treatments with ordinal responses in trials with sequential monitoring and response-adaptive randomization
• Regression analysis for covariate-adaptive randomization: a robust and efficient inference perspective
• The 41\textsuperscript{st} Fisher Memorial Lecture. From Fisher to CARA: the evolution of randomization and randomization-based inference
• Replicable bandits for digital health interventions
• MARGO: machine learning-assisted adaptive randomization for group sequential trials based on overlap weights
• CARA randomization: optimality, inference, enrichment
• Adaptive experiments toward learning treatment effect heterogeneity
• Shift-invariant target in allocation problems
• Multi-objective optimal designs in comparative clinical trials with covariates: the reinforced doubly adaptive biased coin design
• Asymptotic properties of covariate-adaptive randomization
• A covariate-adjusted response-adaptive allocation in clinical trials for a general class of responses
• Efficient quantile covariate adjusted response adaptive experiments
• Response-adaptive treatment allocation for survival trials with clustered right-censored data
• Group response-adaptive randomization with delayed and missing responses
• An optimal response adaptive biased coin design with k heteroscedastic treatments
• Covariate-adjusted response-adaptive randomization in clinical trials using MRI-derived prognostic features
• Efficient randomized-adaptive designs
• A new family of covariate-adjusted response adaptive designs and their properties
• Covariate-adaptive designs with missing covariates in clinical trials
• Handling covariates in the design of clinical trials

This page was built for publication: Asymptotic properties of covariate-adjusted response-adaptive designs

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2642745)