Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping

DOI10.1080/07474946.2019.1611307zbMath1422.62334OpenAlexW2959483276WikidataQ127591748 ScholiaQ127591748MaRDI QIDQ5227806

Guogen Shan, Hua Zhang, Tao Jiang

Publication date: 7 August 2019

Published in: Sequential Analysis (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/07474946.2019.1611307

zbMATH Keywords

branch-and-bound algorithmsample sizeoptimal designadaptive designSimon's optimal design

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05) Sequential statistical design (62L05)

Related Items (3)

Correlation coefficients for a study with repeated measures ⋮ Stopping for efficacy in single-arm phase II clinical trials ⋮ Conservative confidence intervals for the intraclass correlation coefficient for clustered binary data

Cites Work

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• Optimal adaptive two-stage designs for phase II cancer clinical trials
• Adaptive Two-Stage Designs for Single-Arm Phase IIA Cancer Clinical Trials
• Exact confidence limits for the probability of response in two-stage designs

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