Localization of a microtubule organizing center by kinesin motors
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Publication:3302928
Abstract: The microtubule (MT) motor Kip3p is very processive kinesin that promotes catastrophes and pausing in particular on cortical contact. These properties explain the role of Kip3p in positioning the mitotic spindle in budding yeast and potentially other processes controlled by kinesin-8 family members. We present a theoretical approach to positioning of a MT network in a cell. In order to explore the underlying mechanism we introduce an idealized system of two MTs connected by a microtubule organizing center (MTOC). The dynamics of Kip3p is modeled by interacting stochastic particles, which allows us to study the effects of motor-induced depolymerization under spatial confinement. We find that localization in the middle of the system is realized in a parameter regime where the motor densities on the MTs are increasing with the distance from the MTOC. Localization at an asymmetric position is also possible by tuning the kinesin input rates at the MT minus ends or attachment rates depending on different compartments of the cell.
Recommendations
- Motor function in interpolar microtubules during metaphase
- Nonlocal mechanism of self-organization and centering of microtubule asters
- Microtubule patterning in the presence of moving motor proteins
- Molecular mechanism of interaction between kinesin motors affecting their residence times on microtubule lattice and end
- Modeling microtubule-based transport and anchoring of mRNA
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Cited in
(10)- Mechanism of MDCK II cell polarization during the cell division: a computational study
- Nonlocal mechanism of self-organization and centering of microtubule asters
- Motor function in interpolar microtubules during metaphase
- Motor-mediated microtubule self-organization in dilute and semi-dilute filament solutions
- A mathematical model for force generation at the kinetochore-microtubule interface
- Length regulation of microtubules by molecular motors: exact solution and density profiles
- Modeling microtubule-based transport and anchoring of mRNA
- Spatial pattern formation in microtubule post-translational modifications and the tight localization of motor-driven cargo
- Molecular mechanism of interaction between kinesin motors affecting their residence times on microtubule lattice and end
- Microtubule patterning in the presence of moving motor proteins
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