Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial

DOI10.1093/BIOSTATISTICS/KXQ054zbMATH Open1437.62672OpenAlexW2128034658WikidataQ34706540 ScholiaQ34706540MaRDI QIDQ3303671FDOQ3303671

Authors: Min Zhang, Anastasios A. Tsiatis, Marie Davidian, Karen S. Pieper, Kenneth W. Mahaffey 

Publication date: 4 August 2020

Published in: Biostatistics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1093/biostatistics/kxq054

Recommendations

• Distribution-based causal inference models for the estimation of therapy effects in randomized and controled clinic studies.
• Nonparametric inference for assessing treatment efficacy in randomized clinical trials with a time-to-event outcome and all-or-none compliance
• Modeling survival distribution as a function of time to treatment discontinuation: a dynamic treatment regime approach
• Uses and limitations of randomization-based efficacy estimators
• Uses and limitations of randomization-based efficacy estimators

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Inference and missing data
• Estimation of Regression Coefficients When Some Regressors Are Not Always Observed
• A new approach to causal inference in mortality studies with a sustained exposure period—application to control of the healthy worker survivor effect
• Causal effect models for realistic individualized treatment and intention to treat rules

Cited In (3)

• Direct estimation of the mean outcome on treatment when treatment assignment and discontinuation compete
• Modeling survival distribution as a function of time to treatment discontinuation: a dynamic treatment regime approach
• Estimating mean potential outcome under adaptive treatment length strategies in continuous time

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