Information content in data sets for a nucleated-polymerization model

DOI10.1080/17513758.2015.1050465zbMATH Open1443.92090arXiv1503.04682OpenAlexW2964312196WikidataQ30966729 ScholiaQ30966729MaRDI QIDQ3304576FDOQ3304576

Authors: M. Doumic, Carola Kruse, Stéphanie Prigent, H. Thomas Banks, H. Rezaei 

Publication date: 3 August 2020

Published in: Journal of Biological Dynamics (Search for Journal in Brave)

Abstract: We illustrate the use of tools (asymptotic theories of standard error quantification using appropriate statistical models, bootstrapping, model comparison techniques) in addition to sensitivity that may be employed to determine the information content in data sets. We do this in the context of recent models [23] for nucleated polymerization in proteins, about which very little is known regarding the underlying mechanisms; thus the methodology we develop here may be of great help to experimentalists.

Full work available at URL: https://arxiv.org/abs/1503.04682

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zbMATH Keywords

sensitivityuncertainty quantificationinverse problemsinformation contentpolyglutamine and aggregation modelling

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Inverse problems involving ordinary differential equations (34A55) Inverse problems for PDEs (35R30)

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Cited In (5)

• Estimation from moments measurements for amyloid depolymerisation
• Modelling populations ofLygus hesperuson cotton fields in the San Joaquin Valley of California: the importance of statistical and mathematical model choice
• Information content in data sets: a review of methods for interrogation and model comparison
• Use of difference-based methods to explore statistical and mathematical model discrepancy in inverse problems
• Model comparison tests to determine data information content

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