Scaling limit of a discrete prion dynamics model
The authors consider the following two models desribing an intracellular prion infection \[ \frac{dv}{dt}=\lambda-\gamma v-v\sum^\infty_{i=n_0}\tau_iu_i+2\sum_{j\geq n_0}\sum_{i< n_0} ik_{i,j}\beta_ju_j, \] \[ \frac{du_i}{dt}=-\mu_iu_i-\beta_iu_i-v(\tau_iu_i-\tau_{i-1}u_{i-1})+2\sum_{j>i}\beta_jk_{i,j}u_j, \] \(i=n_0,n_0+1,\dots\), with the convention \(\tau_{n_0-1}u_{n_0-1}=0\). Here, \(v\) represents the quantity of healthy monomers, \(u_i\) the quantity of infections polymers of size \(i\). \[ \frac{dv}{dt}=\lambda-\gamma v-v\int^\infty_{x_0}\tau(x){\mathcal U}(t,x)\,dx+2\int^\infty_{x=x_0}\int^{x_0}_{y=0}y k(y,x)\beta(x){\mathcal U}(t,x)\,dx dy, \] \[ \frac{\partial {\mathcal U}}{\partial t}=-\mu(x){\mathcal U}(t,x)-\beta(x){\mathcal U}(t,x)-V\,\frac{\partial}{\partial x}(\tau{\mathcal U})+2\int^\infty_x\beta(y)k(x,y){\mathcal U}(t,y)\,dy, \] with appropriate boundary conditions at \(x=x_0\). The aim of the authors is to investigate the link between both models. They discuss the mathematical assumptions under which the continuous model is the limit of the discrete one, and establish a convergence statement.
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