A reaction-diffusion model of spatial propagation of A oligomers in early stage Alzheimer's disease
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Publication:2661986
Existence problems for PDEs: global existence, local existence, non-existence (35A01) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Statistical mechanics of polymers (82D60) General biology and biomathematics (92B05) Medical applications (general) (92C50)
The authors propose a model dedicated to studying the propagation of Alzheimer's Disease (AD). They build a reaction-diffusion model with a Becker-Döring-like system. By using a theoritical framework and fixed point method, they are able to prove the existence of solutions.
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Cited in
(24)- Comment on the article ``Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome
- Mathematical model of Alzheimer's disease with prion proteins interactions and treatment
- Analysis of a stochastic reaction-diffusion Alzheimer's disease system driven by space-time white noise
- Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome
- A qualitative model for aggregation and diffusion of \(\beta \)-amyloid in Alzheimer's disease
- The progression towards Alzheimer's disease described as a bistable switch arising from the positive loop between amyloids and \(\mathrm{Ca}^{2+}\)
- Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease
- Analysis and numerical simulations of a chemotaxis model of aggregation of microglia in Alzheimer's disease
- A mathematical model for the proliferation, accumulation and spread of pathogenic proteins along neuronal pathways with locally anomalous trapping
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- Simulating the effect of formation of amyloid plaques on aggregation of tau protein
- A qualitative model for aggregation-fragmentation and diffusion of -amyloid in Alzheimer's disease
- An analytical solution simulating growth of Lewy bodies
- Discovering a reaction-diffusion model for Alzheimer's disease by combining PINNs with symbolic regression
- Stability and bifurcation analysis of Alzheimer's disease model with diffusion and three delays
- Neuronal activity induces symmetry breaking in neurodegenerative disease spreading
- A mathematical model on the propagation of tau pathology in neurodegenerative diseases
- A \(\beta\)-protein polymerization in Alzheimer disease: optimal control for nucleation parameter estimation
- Existence of global attractor in reaction-diffusion model of obesity-induced Alzheimer's disease and its control strategies
- Uncertainty quantification for Fisher-Kolmogorov equation on graphs with application to patient-specific Alzheimer's disease
- Optimal control of monomers and oligomers degradation in an Alzheimer's disease model
- A model for the diffusion of A-amyloids in the brain: existence, uniqueness, and qualitative analysis
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