Alzheimer's disease: analysis of a mathematical model incorporating the role of prions
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Medical applications (general) (92C50) Stability in context of PDEs (35B35) Nonlinear ordinary differential operators (34L30) PDEs in connection with biology, chemistry and other natural sciences (35Q92) General biology and biomathematics (92B05) Initial-boundary value problems for systems of nonlinear first-order PDEs (35F61)
Abstract: We introduce a mathematical model of the in vivo progression of Alzheimer's disease with focus on the role of prions in memory impairment. Our model consists of differential equations that describe the dynamic formation of {�eta}-amyloid plaques based on the concentrations of A{�eta} oligomers, PrPC proteins, and the A{�eta}-x-PrPC complex, which are hypothesized to be responsible for synaptic toxicity. We prove the well-posedness of the model and provided stability results for its unique equilibrium, when the polymerization rate of {�eta}-amyloid is constant and also when it is described by a power law.
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Cited in
(26)- The interplay of biochemical and biomechanical degeneration in Alzheimer's disease
- The amyloid cascade hypothesis and Alzheimer's disease: a mathematical model
- A mathematical model on the propagation of tau pathology in neurodegenerative diseases
- Mathematical analysis for stochastic model of Alzheimer's disease
- Oscillations in neuronal activity: a neuron-centered spatiotemporal model of the unfolded protein response in prion diseases
- Stability analysis of a steady state of a model describing Alzheimer's disease and interactions with prion proteins
- Microscopic and macroscopic models for the onset and progression of Alzheimer's disease
- A physical model for dementia
- A fractional-order yeast prion mathematical model and its solution
- From a microscopic to a macroscopic model for Alzheimer disease: two-scale homogenization of the Smoluchowski equation in perforated domains
- Alzheimer's disease and prion: an \textit{in vitro} mathematical model
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- Mathematical model of Alzheimer's disease with prion proteins interactions and treatment
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- Alzheimer's disease: a mathematical model for onset and progression
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- Neuron Scale Modeling of Prion Production with the Unfolded Protein Response
- Analysis and Numerical Simulations of a Reaction-Diffusion Model with Fixed Active Bodies
- Stationary distribution of a stochastic Alzheimer's disease model
- Well-posedness of a mathematical model for Alzheimer's disease
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