Alzheimer's disease: analysis of a mathematical model incorporating the role of prions

DOI10.1007/S00285-013-0732-0zbMATH Open1307.35305arXiv1302.7013OpenAlexW2019289857WikidataQ50876344 ScholiaQ50876344MaRDI QIDQ471079FDOQ471079

Authors: Erwan Hingant, Laurent Pujo-Menjouet, Glenn Webb, M. A. Helal 

Publication date: 13 November 2014

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We introduce a mathematical model of the in vivo progression of Alzheimer's disease with focus on the role of prions in memory impairment. Our model consists of differential equations that describe the dynamic formation of {�eta}-amyloid plaques based on the concentrations of A{�eta} oligomers, PrPC proteins, and the A{�eta}-x-PrPC complex, which are hypothesized to be responsible for synaptic toxicity. We prove the well-posedness of the model and provided stability results for its unique equilibrium, when the polymerization rate of {�eta}-amyloid is constant and also when it is described by a power law.

Full work available at URL: https://arxiv.org/abs/1302.7013

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zbMATH Keywords

stabilitymathematical modelwell-posednessprionAlzheimer

Mathematics Subject Classification ID

Medical applications (general) (92C50) Stability in context of PDEs (35B35) Nonlinear ordinary differential operators (34L30) PDEs in connection with biology, chemistry and other natural sciences (35Q92) General biology and biomathematics (92B05) Initial-boundary value problems for systems of nonlinear first-order PDEs (35F61)

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Cited In (26)

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• The amyloid cascade hypothesis and Alzheimer's disease: a mathematical model
• The interplay of biochemical and biomechanical degeneration in Alzheimer's disease
• Mathematical analysis for stochastic model of Alzheimer's disease
• Oscillations in neuronal activity: a neuron-centered spatiotemporal model of the unfolded protein response in prion diseases
• Stability analysis of a steady state of a model describing Alzheimer's disease and interactions with prion proteins
• Microscopic and macroscopic models for the onset and progression of Alzheimer's disease
• A fractional-order yeast prion mathematical model and its solution
• A physical model for dementia
• Bifurcation analysis and finite-time contraction stability of an Alzheimer disease model
• Alzheimer's disease and prion: an \textit{in vitro} mathematical model
• From a microscopic to a macroscopic model for Alzheimer disease: two-scale homogenization of the Smoluchowski equation in perforated domains
• A continuous-time mathematical model and discrete approximations for the aggregation of \(\beta \)-amyloid
• Finite-time stability and optimal control of a stochastic reaction-diffusion model for Alzheimer's disease with impulse and time-varying delay
• A reaction-diffusion model of spatial propagation of A\(\beta\) oligomers in early stage Alzheimer's disease
• The work of Glenn F. Webb
• Mathematical model of Alzheimer's disease with prion proteins interactions and treatment
• Analysis and numerical simulation of a polymerization model with possible agglomeration process
• Analysis of a model for the dynamics of prions
• Alzheimer's disease: a mathematical model for onset and progression
• A dual-gradient chemotaxis system modeling the spontaneous aggregation of microglia in Alzheimer’s disease
• Neuron Scale Modeling of Prion Production with the Unfolded Protein Response
• A mathematical model demonstrating the role of interstitial fluid flow on the clearance and accumulation of amyloid \(\beta\) in the brain
• Analysis and Numerical Simulations of a Reaction-Diffusion Model with Fixed Active Bodies
• Stationary distribution of a stochastic Alzheimer's disease model
• Well-posedness of a mathematical model for Alzheimer's disease

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