Optimization of an amplification protocol for misfolded proteins by using relaxed control

DOI10.1007/S00285-014-0768-9zbMATH Open1306.49003arXiv1309.2477OpenAlexW3105329555WikidataQ51108548 ScholiaQ51108548MaRDI QIDQ2512934FDOQ2512934

Authors: Jean-Michel Coron, Pierre Gabriel, Peipei Shang 

Publication date: 2 February 2015

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We investigate an optimal control problem which arises in the optimization of an amplification technique for misfolded proteins. The improvement of this technique may play a role in the detection of prion diseases. The model consists in a linear system of differential equations with a nonlinear control. The appearance of oscillations in the numerical simulations is understood by using the Perron and Floquet eigenvalue theory for nonnegative irreductible matrices. Then to overcome the unsolvability of the optimal control, we relax the problem. In the two dimensional case we solve explicitely the optimal relaxed control problem when the final time is large enough.

Full work available at URL: https://arxiv.org/abs/1309.2477

Recommendations

• Optimal geometric control applied to the protein misfolding cyclic amplification process
• Optimal control of a coarse-grained model for protein dynamics
• Optimal control problems of phase relaxation models
• Some relaxation problems in optimal control theory
• scientific article; zbMATH DE number 1594519

zbMATH Keywords

optimal controlPontryagin's maximum principlePerron eigenvaluerelaxed controlFloquet eigenvaluemisfolded proteins

Mathematics Subject Classification ID

Medical applications (general) (92C50) Dynamical systems in biology (37N25) Control problems involving ordinary differential equations (34H05) Existence theories for optimal control problems involving ordinary differential equations (49J15) Methods involving semicontinuity and convergence; relaxation (49J45) Optimality conditions for problems involving ordinary differential equations (49K15)

Cites Work

• Turnpike properties in the calculus of variations and optimal control
• Transport equations in biology.
• Title not available (Why is that?)
• The turnpike property in finite-dimensional nonlinear optimal control
• ANALYSIS OF A CELL-CYCLE SPECIFIC MODEL FOR CANCER CHEMOTHERAPY
• Eigenelements of a general aggregation-fragmentation model
• Prion dynamics with size dependency-strain phenomena
• Title not available (Why is that?)
• Size distribution dependence of prion aggregates infectivity
• A mathematical analysis of the dynamics of prion proliferation
• Analysis of a model for the dynamics of prions
• Self-similarity in a general aggregation-fragmentation problem. Application to fitness analysis
• Scaling limit of a discrete prion dynamics model
• Growth rate and basic reproduction number for population models with a simple periodic factor
• Matrices
• Resonance of the epidemic threshold in a periodic environment
• The shape of the polymerization rate in the prion equation
• Drug resistance in cancer chemotherapy as an optimal control problem
• Optimal bang-bang controls for a two-compartment model in cancer chemotherapy
• Long-time asymptotics for nonlinear growth-fragmentation equations
• Well-posedness for a model of prion proliferation dynamics
• Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models
• Optimal proliferation rate in a cell division model
• On the solvability of a mathematical model for prion proliferation
• Estimating the division rate for the growth-fragmentation equation
• Prion proliferation with unbounded polymerization rates

Cited In (5)

• Identification of the fragmentation role in the amyloid assembling processes and application to their optimization
• Dynamical analysis and optimization of a generalized resource allocation model of microbial growth
• Optimal geometric control applied to the protein misfolding cyclic amplification process
• Discrete limit and monotonicity properties of the Floquet eigenvalue in an age structured cell division cycle model
• Harris's method for non-conservative periodic semiflows and application to some non-local PDEs

This page was built for publication: Optimization of an amplification protocol for misfolded proteins by using relaxed control

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2512934)