Optimization of an amplification protocol for misfolded proteins by using relaxed control

DOI10.1007/S00285-014-0768-9MaRDI QIDQ2512934zbMATH OpenOpenAlexWikidataFDO

Authors Jean-Michel Coron, Pierre Gabriel, Peipei Shang

Publication date 2 February 2015

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1309.2477

zbMATH Keywords

optimal controlPontryagin's maximum principlePerron eigenvaluerelaxed controlFloquet eigenvaluemisfolded proteins

Mathematics Subject Classification ID

Medical applications (general) (92C50) Dynamical systems in biology (37N25) Control problems involving ordinary differential equations (34H05) Existence theories for optimal control problems involving ordinary differential equations (49J15) Methods involving semicontinuity and convergence; relaxation (49J45) Optimality conditions for problems involving ordinary differential equations (49K15)

Abstract: We investigate an optimal control problem which arises in the optimization of an amplification technique for misfolded proteins. The improvement of this technique may play a role in the detection of prion diseases. The model consists in a linear system of differential equations with a nonlinear control. The appearance of oscillations in the numerical simulations is understood by using the Perron and Floquet eigenvalue theory for nonnegative irreductible matrices. Then to overcome the unsolvability of the optimal control, we relax the problem. In the two dimensional case we solve explicitely the optimal relaxed control problem when the final time is large enough.

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Cited in

(5)

• Identification of the fragmentation role in the amyloid assembling processes and application to their optimization
• Dynamical analysis and optimization of a generalized resource allocation model of microbial growth
• Optimal geometric control applied to the protein misfolding cyclic amplification process
• Discrete limit and monotonicity properties of the Floquet eigenvalue in an age structured cell division cycle model
• Harris's method for non-conservative periodic semiflows and application to some non-local PDEs

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