Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models

DOI10.1051/MMNP/20094308MaRDI QIDQ3635227zbMATH OpenOpenAlexFDO

Authors J. Clairambault, Stéphane Gaubert, Thomas Lepoutre

Publication date 6 July 2009

Published in Mathematical Modelling of Natural Phenomena (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0812.0803, https://eudml.org/doc/222182

zbMATH Keywords

averaged coefficientschronotherapycircadian rhythmstime-periodic coefficientstime-periodic control

Mathematics Subject Classification ID

Linear first-order PDEs (35F05) General topics in linear spectral theory for PDEs (35P05) Estimates of eigenvalues in context of PDEs (35P15) Partial functional-differential equations (35R10) General biology and biomathematics (92B05) Population dynamics (general) (92D25)

Abstract: We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clocks, known to exert their influence on the cell division cycle. We compare the growth rate of the model controlled by a time-periodic control on its coefficients with the growth rate of stationary models of the same nature, but with averaged coefficients. We firstly derive a delay differential equation which allows us to prove several inequalities and equalities on the growth rates. We also discuss about the necessity to take into account the structure of the cell division cycle for chronotherapy modeling. Numerical simulations illustrate the results.

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• Ergodic behavior of non-conservative semigroups via generalized Doeblin's conditions
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• Optimization of an amplification protocol for misfolded proteins by using relaxed control
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• Phenotypic plasticity trade-offs in an age-structured model of bacterial growth under stress
• Coupled modeling of DNA damage response in age- and phase-structured tumor cell populations: cell cycle dynamics and therapeutic implications
• Discrete limit and monotonicity properties of the Floquet eigenvalue in an age structured cell division cycle model

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