An inequality for the Perron and Floquet eigenvalues of monotone differential systems and age structured equations

DOI10.1016/J.CRMA.2007.10.001MaRDI QIDQ2464271zbMATH OpenOpenAlexWikidataFDO

Authors J. Clairambault, Stéphane Gaubert, Ben{ôı}t Perthame

Publication date 12 December 2007

Published in Comptes Rendus. Mathématique. Académie des Sciences, Paris (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0704.3820

Mathematics Subject Classification ID

Characteristic and Lyapunov exponents of ordinary differential equations (34D08) Population dynamics (general) (92D25)

Abstract: For monotone linear differential systems with periodic coefficients, the (first) Floquet eigenvalue measures the growth rate of the system. We define an appropriate arithmetico-geometric time average of the coefficients for which we can prove that the Perron eigenvalue is smaller than the Floquet eigenvalue. We apply this method to Partial Differential Equations, and we use it for an age-structured systems of equations for the cell cycle. This opposition between Floquet and Perron eigenvalues models the loss of circadian rhythms by cancer cells.

Review text

Consider a \(T\)-periodic linear system \[ \dot{x}=A(t)x, \] where the entries of the matrix \(A(t)\) are nonnegative. The first Floquet eigenvalue, \(\lambda_{\text{per}}\), is the maximal number \(\lambda\) for which the system \[ \dot{x}=A(t)x-\lambda x \] has a nontrivial \(T\)-periodic solution with nonnegative elements. The authors estimate the value \(\lambda_{\text{per}}\) using averages of entries of the matrix \(A(t)\). As an application, they consider a system arising in population dynamics.

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Cites work

• Circadian rhythm and tumour growth
• General relative entropy inequality: an illustration on growth models
• scientific article; zbMATH DE number 3995502 (Why is no real title available?)
• Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms
• Transport equations in biology.

Cited in

(13)

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• Synchronisation and control of proliferation in cycling cell population models with age structure
• Optimization of additive chemotherapy combinations for an in vitro cell cycle model with constant drug exposures
• Time fluctuations in a population model of adaptive dynamics
• Analysis of a population model structured by the cells molecular content
• Eigenelements of a general aggregation-fragmentation model
• Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models
• Self-similarity in a general aggregation-fragmentation problem. Application to fitness analysis
• Physiologically structured cell population dynamic models with applications to combined drug delivery optimisation in oncology
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• Phenotypic plasticity trade-offs in an age-structured model of bacterial growth under stress
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