Circadian rhythm and cell population growth

DOI10.1016/J.MCM.2010.05.034zbMATH Open1219.35323arXiv1006.3459OpenAlexW1980825545MaRDI QIDQ636418FDOQ636418

Authors: J. Clairambault, Stéphane Gaubert, Thomas Lepoutre 

Publication date: 28 August 2011

Published in: Mathematical and Computer Modelling (Search for Journal in Brave)

Abstract: Molecular circadian clocks, that are found in all nucleated cells of mammals, are known to dictate rhythms of approximately 24 hours (circa diem) to many physiological processes. This includes metabolism (e.g., temperature, hormonal blood levels) and cell proliferation. It has been observed in tumor-bearing laboratory rodents that a severe disruption of these physiological rhythms results in accelerated tumor growth. The question of accurately representing the control exerted by circadian clocks on healthy and tumour tissue proliferation to explain this phenomenon has given rise to mathematical developments, which we review. The main goal of these previous works was to examine the influence of a periodic control on the cell division cycle in physiologically structured cell populations, comparing the effects of periodic control with no control, and of different periodic controls between them. We state here a general convexity result that may give a theoretical justification to the concept of cancer chronotherapeutics. Our result also leads us to hypothesize that the above mentioned effect of disruption of circadian rhythms on tumor growth enhancement is indirect, that, is this enhancement is likely to result from the weakening of healthy tissue that are at work fighting tumor growth.

Full work available at URL: https://arxiv.org/abs/1006.3459

Recommendations

• Circadian rhythm and tumour growth
• Modeling circadian clock-cell cycle interaction effects on cell population growth rates
• Modeling biological rhythms in cell populations
• Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models
• Synchronisation and control of proliferation in cycling cell population models with age structure

zbMATH Keywords

cancereigenvaluesmathematical biologypartial differential equationscircadian rhythmsgrowth processesphysiologically structured models

Mathematics Subject Classification ID

Population dynamics (general) (92D25) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biological rhythms and synchronization (92B25) Boundary value problems for linear first-order PDEs (35F15)

Cites Work

• General relative entropy inequality: an illustration on growth models
• Analysis of a molecular structured population model with possible polynomial growth for the cell division cycle
• An age-and-cyclin-structured cell population model for healthy and tumoral tissues
• A CONVEXITY PROPERTY OF POSITIVE MATRICES
• Analysis of a population model structured by the cells molecular content
• An inequality for the Perron and Floquet eigenvalues of monotone differential systems and age structured equations
• Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models
• Circadian rhythm and tumour growth

Cited In (14)

• Modeling circadian clock-cell cycle interaction effects on cell population growth rates
• Modeling biological rhythms in cell populations
• Long-term treatment effects in chronic myeloid leukemia
• Circadian rhythm and tumour growth
• Optimisation of cancer drug treatments using cell population dynamics
• A multiscale modelling approach for the regulation of the cell cycle by the circadian clock
• Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers
• Discrete limit and monotonicity properties of the Floquet eigenvalue in an age structured cell division cycle model
• On the relationship between cell cycle analysis with ergodic principles and age-structured cell population models
• Mathematical methods and modelling of biophysical phenomena
• Clocked cell cycle clocks
• Physiologically Structured Cell Population Dynamic Models with Applications to Combined Drug Delivery Optimisation in Oncology
• Synchronisation and control of proliferation in cycling cell population models with age structure
• Cell size homeostasis under the circadian regulation of cell division in cyanobacteria

This page was built for publication: Circadian rhythm and cell population growth

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q636418)