Control law design for propofol infusion to regulate depth of hypnosis: a nonlinear control strategy
Summary: Maintaining the depth of hypnosis (DOH) during surgery is one of the major objectives of anesthesia infusion system. Continuous administration of Propofol infusion during surgical procedures is essential but increases the undue load of an anesthetist in operating room working in a multitasking setup. Manual and target controlled infusion (TCI) systems are not good at handling instabilities like blood pressure changes and heart rate variability arising due to interpatient variability. Patient safety, large interindividual variability, and less postoperative effects are the main factors to motivate automation in anesthesia. The idea of automated system for Propofol infusion excites the control engineers to come up with a more sophisticated and safe system that handles optimum delivery of drug during surgery and avoids postoperative effects. In contrast to most of the investigations with linear control strategies, the originality of this research work lies in employing a nonlinear control technique, backstepping, to track the desired hypnosis level of patients during surgery. This effort is envisioned to unleash the true capabilities of this nonlinear control technique for anesthesia systems used today in biomedical field. The working of the designed controller is studied on the real dataset of five patients undergoing surgery. The controller tracks the desired hypnosis level within the acceptable range for surgery.
- Comparison of two nonlinear control strategies for hypnosis regulation
- Optimized PID control of propofol and remifentanil coadministration for general anesthesia
- Observer design estimating the propofol concentration in PKPD model with feedback control of anesthesia administration
- A robust model predictive control framework for the regulation of anesthesia process with propofol
- Robust control of depth of anesthesia based on H∞ design
- Comparison of two nonlinear control strategies for hypnosis regulation
- Inversion-based propofol dosing for intravenous induction of hypnosis
- Optimized PID control of propofol and remifentanil coadministration for general anesthesia
- Robust control of depth of anesthesia
- Feedforward adaptive control of the Bispectral Index of the EEG using the intravenous anaesthetic drug propofol
- NMPC for propofol drug dosing during anesthesia induction
- A switching control strategy for improving drug infusion
- scientific article; zbMATH DE number 1254069 (Why is no real title available?)
- scientific article; zbMATH DE number 2044648 (Why is no real title available?)
- Feedback law with probabilistic certification for propofol-based control of BIS during anesthesia
- Robust control of depth of anesthesia based on H∞ design
- Observer design estimating the propofol concentration in PKPD model with feedback control of anesthesia administration
- Switched control strategy including time optimal control and robust dynamic output feedback for anaesthesia
- Reference tracking of depth of anesthesia using optimal control
- Event-based control tuning of propofol and remifentanil coadministration for general anaesthesia
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