A singular limit for an age structured mutation problem

DOI10.3934/MBE.2017002zbMATH Open1352.35197arXiv1605.07788OpenAlexW2397157154WikidataQ50544170 ScholiaQ50544170MaRDI QIDQ335235FDOQ335235

Authors: Jacek Banasiak, Aleksandra Falkiewicz 

Publication date: 2 November 2016

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Abstract: The spread of a particular trait in a cell population often is modelled by an appropriate system of ordinary differential equations describing how the sizes of subpopulations of the cells with the same genome change in time. On the other hand, it is recognized that cells have their own vital dynamics and mutations, leading to changes in their genome, mostly occurring during the cell division at the end of its life cycle. In this context, the process is described by a system of McKendrick type equations which resembles a network transport problem. In this paper we show that, under an appropriate scaling of the latter, these two descriptions are asymptotically equivalent.

Full work available at URL: https://arxiv.org/abs/1605.07788

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zbMATH Keywords

age structurepopulation dynamicssingularly perturbed dynamical systemsasymptotic state lumpingLebowitz-rotenberg modelmutation model

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Asymptotic behavior of solutions to PDEs (35B40) Singular perturbations for ordinary differential equations (34E15) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Multiple scale methods for ordinary differential equations (34E13)

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Cited In (4)

• A note on generalized Euler's formula
• Generalized network transport and Euler-Hille formula
• Transport on networks -- a playground of continuous and discrete mathematics in population dynamics
• Bi-continuous semigroups for flows on infinite networks

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