Mathematical modelling for malaria under resistance and population movement

DOI10.18273/REVINT.V38N2-2020006MaRDI QIDQ3390637zbMATH OpenOpenAlexFDO

Authors Cristhian Montoya, Jhoana P. Romero-Leiton

Publication date 25 March 2022

Published in Revista integración, temas de matemáticas (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NoDerivs 4.0 International

Full work available at URL https://arxiv.org/abs/2002.00070

zbMATH Keywords

stabilitybifurcationqualitative analysisinsecticidesantimalarial drug

Mathematics Subject Classification ID

Epidemiology (92D30) Stability of solutions to ordinary differential equations (34D20) Existence theories for optimal control problems involving ordinary differential equations (49J15) Pest management (92D45)

Abstract: In this work, two mathematical models for malaria under resistance are presented. More precisely, the first model shows the interaction between humans and mosquitoes inside a patch under infection of malaria when the human population is resistant to antimalarial drug and mosquitoes population is resistant to insecticides. For the second model, human-mosquitoes population movements in two patches is analyzed under the same malaria transmission dynamic established in one patch. For a single patch, existence and stability conditions for the equilibrium solutions in terms of the local basic reproductive number are developed. These results reveal the existence of a forward bifurcation and the global stability of disease-free equilibrium. In the case of two patches, a theoretical and numerical framework on sensitivity analysis of parameters is presented. After that, the use of antimalarial drugs and insecticides are incorporated as control strategies and an optimal control problem is formulated. Numerical experiments are carried out in both models to show the feasibility of our theoretical results.

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Cited in

(7)

• Mathematical analysis of reinfection and relapse in malaria dynamics
• A mathematical model of Malaria transmission dynamics in genetically resistant and susceptible population
• Malaria drug resistance: the impact of human movement and spatial heterogeneity
• Mathematical modelling of drug resistant malaria parasites and vector populations
• Mathematical model for the spread of drug resistance in \textit{Plasmodium falciparum} parasite considering transmission conditions
• Mathematical models for within-host competition of malaria parasites
• Mathematical analysis to prioritise strategies for malaria elimination

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