An attraction-repulsion point process model for respiratory syncytial virus infections

DOI10.1111/BIOM.12267zbMATH Open1390.62261arXiv1401.5506OpenAlexW1554112905WikidataQ41467045 ScholiaQ41467045MaRDI QIDQ3459935FDOQ3459935

Authors: Joshua R. Goldstein, Murali Haran, Ivan Simeonov, John Fricks, Francesca Chiaromonte 

Publication date: 11 January 2016

Published in: Biometrics (Search for Journal in Brave)

Abstract: How is the progression of a virus influenced by properties intrinsic to individual cells? We address this question by studying the susceptibility of cells infected with two strains of the human respiratory syncytial virus (RSV-A and RSV-B) in an in vitro experiment. Spatial patterns of infected cells give us insight into how local conditions influence susceptibility to the virus. We observe a complicated attraction and repulsion behavior, a tendency for infected cells to lump together or remain apart. We develop a new spatial point process model to describe this behavior. Inference on spatial point processes is difficult because the likelihood functions of these models contain intractable normalizing constants; we adapt an MCMC algorithm called double Metropolis-Hastings to overcome this computational challenge. Our methods are computationally efficient even for large point patterns consisting of over 10,000 points. We illustrate the application of our model and inferential approach to simulated data examples and fit our model to various RSV experiments. Because our model parameters are easy to interpret, we are able to draw meaningful scientific conclusions from the fitted models.

Full work available at URL: https://arxiv.org/abs/1401.5506

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zbMATH Keywords

Markov chain Monte Carlospatial point processintractable normalizing constantvirus infections

Mathematics Subject Classification ID

Inference from spatial processes (62M30) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited In (11)

• Identifying crash risk factors and high risk locations on an interstate network
• A spatio-temporal Dirichlet process mixture model for coronavirus disease-19
• Use of mathematical modelling to assess respiratory syncytial virus epidemiology and interventions: a literature review
• Effect of vitamin A deficiency on respiratory infection: causal inference for a discretely observed continuous time non-stationary Markov process
• The Clustering of Infected SIV Cells in Lymphatic Tissue
• Bayesian inference in the presence of intractable normalizing functions
• A Function Emulation Approach for Doubly Intractable Distributions
• Randomness in a mathematical model for the transmission of respiratory syncytial virus (RSV)
• Dynamic models of animal movement with spatial point process interactions
• Bayesian indirect inference for models with intractable normalizing functions
• Modelling aggregation on the large scale and regularity on the small scale in spatial point pattern datasets

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