An approach to confirmatory testing of subpopulations in clinical trials

DOI10.1002/BIMJ.201400006zbMATH Open1336.62011OpenAlexW1847128154WikidataQ85274957 ScholiaQ85274957MaRDI QIDQ3465347FDOQ3465347

Authors: Ekkehard Glimm, Lilla di Scala 

Publication date: 21 January 2016

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.201400006

Recommendations

• A multiple comparison procedure for dose-finding trials with subpopulations
• Correct and logical inference on efficacy in subgroups and their mixture for binary outcomes
• Optimal tests of treatment effects for the overall population and two subpopulations in randomized trials, using sparse linear programming
• Confidence regions for treatment effects in subgroups in biomarker stratified designs
• Adaptive designs for subpopulation analysis optimizing utility functions

zbMATH Keywords

stratifiedmodel-basedbiomarkersubpopulationssuper-responders

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Cites Work

• Title not available (Why is that?)
• Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests
• A Multiple Comparison Procedure for Comparing Several Treatments with a Control
• The two-sample \(t\) test: pre-testing its assumptions does not pay off
• A Step-Up Multiple Test Procedure
• Power gain by pre-testing?

Cited In (1)

• Statistical verification of PCTL using antithetic and stratified samples

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