Confidence regions for treatment effects in subgroups in biomarker stratified designs

DOI10.1002/BIMJ.201700303MaRDI QIDQ4626705zbMATH OpenOpenAlexWikidataFDO

Authors Fang Wan, Cornelia U. Kunz, Thomas Jaki

Publication date 28 February 2019

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://eprints.lancs.ac.uk/id/eprint/128061/1/subgroup.pdf

zbMATH Keywords

treatment effectssubgroupconfidence regionbiomarker stratified design

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Nonparametric tolerance and confidence regions (62G15) Response surface designs (62K20)

Recommendations

• Patterns of treatment effects in subsets of patients in clinical trials
• Adaptive designs for subpopulation analysis optimizing utility functions
• A Bayesian credible subgroups approach to identifying patient subgroups with positive treatment effects
• Analysis of subgroup effects in randomized trials when subgroup membership is missing: application to the second multicenter automatic defibrillator intervention trial
• Confident inference for SNP effects on treatment efficacy

Cites work

• Computation of multivariate normal and \(t\) probabilities
• Interval estimation for a binomial proportion. (With comments and a rejoinder).
• Multiple Comparisons Among Means
• Simple and Effective Confidence Intervals for Proportions and Differences of Proportions Result from Adding Two Successes and Two Failures

Cited in

(2)

• An approach to confirmatory testing of subpopulations in clinical trials
• Patterns of treatment effects in subsets of patients in clinical trials

Describes a project that uses

Uses Software

• mvtnorm

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