More powerful genetic association testing via a new statistical framework for integrative genomics

DOI10.1111/BIOM.12206zbMATH Open1393.62115OpenAlexW1912093789WikidataQ40464337 ScholiaQ40464337MaRDI QIDQ3465366FDOQ3465366

Authors:

Publication date: 21 January 2016

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc4425276

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zbMATH Keywords

genome-wide association studiesmediation analysismissing heritabilityintegrative genomicsgenetic association testing

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Cites Work

• Confidence Intervals and Hypothesis Testing for High-Dimensional Regression
• Title not available (Why is that?)
• On asymptotically optimal confidence regions and tests for high-dimensional models
• Informative Drop-Out in Longitudinal Data Analysis
• Logistic disease incidence models and case-control studies
• Covariate-adjusted precision matrix estimation with an application in genetical genomics
• Mediation Analysis with Multiple Mediators
• A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies

Cited In (7)

• Hypothesis test of mediation effect in causal mediation model with high‐dimensional continuous mediators
• Sparse principal component based high-dimensional mediation analysis
• Power of testing for exposure effects under incomplete mediation
• A combined \(p\)-value approach to infer pathway regulations in eQTL mapping
• Using ascertainment for targeted resequencing to increase power to identify causal variants
• Model-based hypothesis tests for the causal mediation of semi-competing risks
• Nonlinear joint latent variable models and integrative tumor subtype discovery

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