Semi-algebraic geometry of common lines

DOI10.1186/S40687-014-0014-5zbMATH Open1349.92078arXiv1402.5462OpenAlexW2171623596WikidataQ59401337 ScholiaQ59401337MaRDI QIDQ347459FDOQ347459

Authors: David Dynerman 

Publication date: 30 November 2016

Published in: Research in the Mathematical Sciences (Search for Journal in Brave)

Abstract: Cryo-electron microscopy is a technique in structural biology for discovering/determining the 3D structure of small molecules. A key step in this process is detecting common lines of intersection between unknown embedded image planes. We intrinsically characterize such common lines in terms of the unembedded geometric data detected in experiments. We show these common lines form a semi-algebraic set, i.e., they are defined by polynomial equalities and inequalities. These polynomials are low degree and, using techniques from spherical geometry, we explicitly derive them in this paper.

Full work available at URL: https://arxiv.org/abs/1402.5462

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zbMATH Keywords

3D structure of macromoleculescommon lines

Mathematics Subject Classification ID

Biomedical imaging and signal processing (92C55) Image processing (compression, reconstruction, etc.) in information and communication theory (94A08) Computing methodologies for image processing (68U10)

Cites Work

• Three-dimensional structure determination from common lines in cryo-EM by eigenvectors and semidefinite programming
• Representation theoretic patterns in three dimensional cryo-electron microscopy. I: The intrinsic reconstitution algorithm

Uses Software

• Macaulay2

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