Interval estimation for drop-the-losers designs

DOI10.1093/BIOMET/ASQ003zbMATH Open1406.62087OpenAlexW1975735320MaRDI QIDQ3585403FDOQ3585403

Weizhen Wang, Samuel S. Wu, Mark C. K. Yang

Publication date: 19 August 2010

Published in: Biometrika (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1093/biomet/asq003

Recommendations

• Drop-the-losers design: binomial case
• Drop-the-losers design: normal case
• Parameter estimation following an adaptive treatment selection trial design
• Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop-the-losers trials
• Likelihood inference for a two-stage design with treatment selection

zbMATH Keywords

clinical trialadaptive designtwo-stage test\(p\)-value combinationdrop-the-losers design

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Design of statistical experiments (62K99)

Cited In (7)

• On estimating the mean of the selected normal population in two-stage adaptive designs
• Title not available (Why is that?)
• Admissible and minimax estimation of the parameters of the selected normal population in two-stage adaptive designs under reflected normal loss function
• Confidence intervals for confirmatory adaptive two‐stage designs with treatment selection
• Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop‐the‐losers trials
• Confidence intervals for the selected population in randomized trials that adapt the population enrolled
• A comparison of methods for constructing confidence intervals after phase II/III clinical trials

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