Identification of a pharmacokinetic two-compartment model application to the case of salicylates administered to rabbit

DOI10.1016/0270-0255(86)90079-5MaRDI QIDQ3748859zbMATH OpenOpenAlexFDO

Authors Walter Geisz, M. Bourin

Publication date 1986

Published in Mathematical Modelling (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0270-0255(86)90079-5

zbMATH Keywords

rate constantseliminationtransferabsorptionnumerical testsdrug kineticsrabbitsfirst-order kineticscoupled linear differential equationsAspirincomputer simulation studyfinite difference discretization methodlysine acetylsalicylatenonlinear programming method of conjugate-gradient typeoptimal therapeutic treatmentspharmacokinetic two-compartment open modelsodium salicylate

Mathematics Subject Classification ID

Medical applications (general) (92C50) Nonlinear programming (90C30) System identification (93B30) Linear systems in control theory (93C05) Control/observation systems governed by ordinary differential equations (93C15) Physiological, cellular and medical topics (92Cxx)

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