Nonparametric estimation of dose-response curves with application to ED50 estimation

DOI10.1080/00949658708811004MaRDI QIDQ3759779zbMATH OpenOpenAlexFDO

Authors Russell F. Kappenman

Publication date 1987

Published in Journal of Statistical Computation and Simulation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1080/00949658708811004

zbMATH Keywords

cross-validationrobust estimationkernel estimatorsample reusesimulation studiesED 50median effective dosedose response curve estimation proceduretrimmed Spearman-Kärber estimation

Mathematics Subject Classification ID

Nonparametric estimation (62G05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Kernel and Probit Estimates in Quantal Bioassay
• A Note on Nonparametric Estimation of the Effective Dose in Quantal Bioassay
• Kernel Estimates of Dose Response
• Consistency and asymptotic normality of the estimated effective doses in bioassay
• A finite sample comparison of nonparametric estimates of the effective dose in quantal bioassay

Cites work

• scientific article; zbMATH DE number 3617410 (Why is no real title available?)
• A nonparametric data based univariate density function estimate
• An Efficient R-Estimator for the ED50
• Robust estimators for quantal bioassay

Cited in

(14)

• Monotone B-Spline Smoothing for a Generalized Linear Model Response
• A comparative study of the dose-response analysis with application to the target dose estimation
• On the Use of Nonparametric Curves in Phase I Trials with Low Toxicity Tolerance
• Interval estimation of the \(ED_{50}\) when a logistic dose-response curve is incorrectly assumed
• A finite sample comparison of nonparametric estimates of the effective dose in quantal bioassay
• Sigmoidally Constrained Maximum Likelihood Estimation in Quantal Bioassay
• A Note on Nonparametric Estimation of the Effective Dose in Quantal Bioassay
• Parametric and nonparametric estimators of ED100α
• Consistency and asymptotic normality of the estimated effective doses in bioassay
• A survey of literature on quantal response curves with a view toward application to the problem of selecting the curve with the smallest q-quantile (ediooq)
• Choice of Number of Doses for Maximum Likelihood Estimation of the ED50 for Quantal Dose-Response Data
• Kernel Estimates of Dose Response
• Asymptotically unbiased estimates of a distribution function in dose effect relationships
• Selection of number of dose levels and its robustness for binary response data

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